Exploration of the Hematological Profile of Male Sprague-Dawley Rats after Chronic Administration of an Ayurvedic Formulation Punarnavasava (PRV) Used in Ascites Treatment
Received Date: Jun 30, 2020 / Accepted Date: Jul 15, 2020 / Published Date: Jul 22, 2020
Abstract
Punarnavasava (PRV) is a classical Ayurvedic preparation and is very popular in rural areas due to its usage in the treatment of ascites. This study was conducted to explore the hemotoxicological effect of PRV after chronic administrations for 45 days to male Sprague-Dawley rats. After the observations, there were statistically significant changes in Basophil and Lymphocyte count (p=0.020 and p=0.032 respectively) but showed negligible changes for other hematological parameters like RBC, Hemoglobin, Hematocrit, Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), Erythrocyte sedimentation rate (ESR), etc. From these results, it can be concluded that PRV is less hemotoxic at higher doses and thus can be recommended to use safely in the treatment of ascites.
Keywords: Punarnavasava; Ascites; Hemotoxicity; Ayurvedic; RBC; WBC
Citation: Rahman MA, Amin MT, Aziz MA, Fatema K, Karmakar P, et al. (2020) Exploration of the Hematological Profile of Male Sprague-Dawley Rats after Chronic Administration of an Ayurvedic Formulation Punarnavasava (PRV) Used in Ascites Treatment. J Tradit Med Clin Natur 9: 287. Doi: 10.4172/2573-4555.1000287
Copyright: © 2020 Rahman MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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