Neuropathy is a disorder that occurs when these nerves malfunction because they are damaged or destroyed. This disrupts the nerves’ normal functioning. They might send signals of pain when there is nothing causing pain, or they might not send a pain signal even if something is harming you. This can be caused by injury, systemic illness, infection, or may be associated with an inherited disorder. neuropathy causes Diabetes, B12 or folate vitamin deficiencies, Cancers, Chronic kidney disease.