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Giant Gastric Folds: A Presentation of POEMS Syndrome | OMICS International
ISSN: 2161-069X
Journal of Gastrointestinal & Digestive System

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Giant Gastric Folds: A Presentation of POEMS Syndrome

Katsuya Chinen*

Department of Pathology, Nerima General Hospital, 1-24-1 Asahigaoka, Nerima, Tokyo, Japan

*Corresponding Author:
Katsuya Chinen
Department of Pathology
Nerima General Hospital
1-24-1 Asahigaoka
Nerima, Tokyo, Japan
Tel: 81-3-5988-2200

Received date: April 01, 2013; Accepted date: May 29, 2013; Published date: May 31, 2013

Citation: Chinen K (2013) Giant Gastric Folds: A Presentation of POEMS Syndrome. J Gastroint Dig Syst S12:010. doi:10.4172/2161-069X.S12-010

Copyright: © 2013 Chinen K. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Giant gastric folds; POEMS syndrome; Organomegaly

A 42-year-old woman presented with dyspnea on exertion and was diagnosed as having idiopathic pulmonary hypertension (PH). In spite of PH-specific therapies, her PH did not improve. In the clinical course, she presented with polyneuropathy, hepatomegaly, and increased serum level of immunoglobulin G. Four months prior to death, she developed nausea, vomiting, poor appetite, and malnutrition and she eventually died of respiratory failure at the age of 49. An autopsy revealed that the PH was attributed to stenosis of the pulmonary vasculature affected by plasma cell myeloma. In addition, multisystem organomegaly was apparent. Also, marked enlargement of rugal folds (giant folds) was identified throughout the stomach (Figure 1). Histologically, the gastric giant folds were caused by prominent hyperplasia of the foveolar epithelium (Figure 2). Based on the clinical and autopsy findings, the present case was finally diagnosed as PH associated with POEMS syndrome (coined to refer to polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) [1].


Figure 1: Marked enlargement of rugal folds (giant folds) was apparent for the whole stomach.


Figure 2: Microphotograph of the stomach illustrating marked foveolar hyperplasia. Note that the surface layer is about 3 to 4 times as thick as the layer of fundic glands.

Giant gastric folds develop in several benign and malignant diseases such as Menetrier disease, anisakiasis, acute gastric mucosal lesion, gastric lymphoma, and scirrhous carcinoma [2]. However, the patient did not have such diseases and the giant gastric folds could be regarded as “gastric organomegaly” in the POEMS syndrome. This case indicates that the POEMS syndrome should be included in the list of differential diagnosis for giant gastric folds.


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