Reach Us +1-947-333-4405
An Ultra-rare Hereditary Disease of 28–year Old Pregnant Patient withMalignant Alteration
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

An Ultra-rare Hereditary Disease of 28–year Old Pregnant Patient withMalignant Alteration

Vuka Katic1*, Zoran Radovanovic1, Aleksandra Karadzic1, Goran Rankovic2, Ivan Nagorni1, Aleksandar Rankovic1 and Ivana Golubovic1
1Policlinic Human, Nis University, Serbia
2Faculty for Sports, Nis University, Serbia
*Corresponding Author: Vuka Katic, Policlinic Human, Nis University, Serbia, Tel: 0038118533190, Email: [email protected]

Received Date: Nov 23, 2018 / Accepted Date: Dec 06, 2018 / Published Date: Dec 12, 2018


Familial adenomatous polyposis (FAP) is an autosomal dominant disorder characterized by the development of hundreds to thousands of colorectal adenomatous polyps and the inevitable occurrence of colorectal carcinoma, if the colon is not removed. In a 28-year old patient, following diagnostic criteria, have been established more than 500 colorectal adenomas and family history of FAP.

Keywords: Colorectal; Carcinoma; Adenocarcinoma; Rectal carcinoma; Antibodies


Having in the mind that the colorectal carcinoma is the most frequent carcinoma of the digestive system, and that often arises from adenoma by Marson’s “adenoma-carcinoma sequence” theory, we have undertaken the following study: morphological, histochemical and immunohistochemical examinations of one hundred adenomas of various size and macroscopically pattern in FAP, complicated by rectal mucinous adenocarcinoma.

Material and Methods

Total colectomy was induced by FAP, associated with rectal carcinoma. Numerous hundreds of tubulars, tubulo-villous and villous adenomas, size from 5 to 35 mm, as well as 10 biopsies of the cancerous rectal tissue, together with 10 regional lymph nodes, were fixed in 10% formaldehyde and processed in auto technicon. Paraffin sections of 2 microns were stained with; classic H&E method, histochemical PAS, HID-AB, pH2.5 methods as well as immunohistochemical ABC method, by using antibodies to; Ki-67 (mitotic activity), p53 suppressor activity and CEA (marker for colonic adenocarcinoma) [1-5].


Most polyps were small, sessile and lobulated, “carpeting” the lining of the whole large bowel and numbering hundreds (Figures 1 and 2). Scattered larger sessile and pedunculated polyps were much less common, but the largest was surrounded by mucinous infiltrative rectal carcinoma (Figure 2). Histopathological, wide spectrum of size, structure and dysplasia of adenomas was obsreved (Figures 3-5). Malignant alteration of tubular adenoma with mucinous secretion was also seen (Figures 6 and 7). Strong mucinous secretion was found in both villous adenoma and mucinous adenocarcinoma (Figures 8 and 9).


Figure 1: Hundreds of adenomas and rectal carcinoma.


Figure 2: Large size of villous adenomas – arrows.


Figure 3: Various size and villous structure of adenomas.


Figure 4: Normal colonic mucosa with normal secretio of sulfo– mucin.


Figure 5: Adenoma tubulo-villosum cum dysplasio gr. II et cum hiposrcretio sulfo-mucin.


Figure 6: Adenoma-tubullare cum alteratio maligna et cum asecretio (arrow).


Figure 7: Micro adenoma collonis cum hypo-asecretio (arrow).


Figure 8: Adenoma-vilosum cum hypersecretion, sulfo- mucin.


Figure 9: Adenocarcinoma mucinosum cum hypersecretion sialosulfo mucin.

High expression of proliferative nuclear activity (Ki-67 antigen) was also observed (Figures 10 and 11). Strong p53 nuclear activity of the suppressor gene in adenocarcinoma has also been found (Figure 12) [5-7].


Figure 10: High mitotic superfitial Ki-67 nuclear activity.


Figure 11: Diffuse mitotic activity in adenocarcinoma.


Figure 12: Rectal carcinoma with strong p53 activity.


We have confirmed the theory “adenoma-carcinoma sequence”, showing that size, villous structure, severe dysplasia, as well as their number, represent the risk factors in colorectal carcinogenesis [7-9]. On the basis of the expression of normal HID and coexpression of small intestinal AB-mucin in both villous adenoma and surrounding mucinous adenocarcinoma, we have pointed out the direct connection between villous adenoma and mucinous colorectal adenocarcinoma. The discovery of the malignant alteration of the FAP in very young (28-years old) patient, could be explained by her pregnant state with decreased host immunity [10-14].


Citation: Katic V, Radovanovi Z, Karadzic A, Rankovic G, Nagorni I, et al. (2018) An Ultra-rare Hereditary Disease of 28–year Old Pregnant Patient with Malignant Alteration. J Infect Dis Ther 7:388. DOI: 10.4172/2332-0877.1000388

Copyright: © 2018 Katic V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Relevant Topics
Article Usage
  • Total views: 268
  • [From(publication date): 0-0 - May 23, 2019]
  • Breakdown by view type
  • HTML page views: 238
  • PDF downloads: 30