The Neurologist: Clinical & Therapeutics Journal - Causes of Parkinson's Disease

The Neurologist: Clinical & Therapeutics Journal
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Letter To Editor   
  • Neurol Clin Therapeut J, Vol 6(3)
  • DOI: 10.4172/nctj.1000122

Causes of Parkinson's Disease

Risna Radhakrishnan*
Department of Animal Science, Bharathidasan University, Tamil Nadu, India
*Corresponding Author: Risna Radhakrishnan, Department of Animal Science, Bharathidasan University, Tamil Nadu, India, Email: [email protected]

Manuscript No. nctj-22-63590 / Editor assigned: 04-May-2022 / PreQC No. nctj-22-63590 (PQ) / Reviewed: 11-May-2022 / QC No. nctj-22- 63590 / Revised: 14-May-2022 / Manuscript No. nctj-22-63590 (R) / Published Date: 21-May-2022 DOI: 10.4172/nctj.1000122

Parkinson’s complaint (PD), or simply Parkinson’s, is a long- term degenerative complaint of the central nervous system that substantially affects the motor system [1]. The symptoms generally crop sluggishly, and as the complaint worsens, non-motor symptoms come more common. The most egregious early symptoms are earthquake, severity, slowness of movement, and difficulty with walking. Cognitive and behavioral problems may also do with depression, anxiety, and apathy being in numerous people with PD. Parkinson’s complaint madness becomes common in the advanced stages of the complaint. Those with Parkinson’s can also have problems with their sleep and sensitive systems. The motor symptoms of the complaint result from the death of cells in the substantia nigra, a region of the midbrain, leading to a dopamine deficiency. The cause of this cell death is inadequately understood, but involves the figure-up of misfolded proteins into Lewy bodies in the neurons. Inclusively, the main motor symptoms are also known as Parkinsonism or a parkinsonian pattern.

The cause of PD is unknown, with both inherited and environmental factors believed to play a part. Those with an affected family member are at an increased threat of getting the complaint, with certain genes known to be heritable threat factors [2]. Other threat factors are those who have been exposed to certain fungicides and who have previous head injuries. Coffee alkies, tea alkies, and tobacco smokers are at a reduced threat.


Numerous threat factors have been proposed, occasionally in relation to propositions concerning possible mechanisms of the complaint; still, none has been proven conclusively. The most constantly replicated connections are an increased threat in those exposed to fungicides, and a reduced threat in smokers. A possible link exists between PD and Helicobacter pylori infection that can help the immersion of some medicines, including levodopa


Exploration indicates that PD is the product of a complex commerce of inheritable and environmental factors. Around 15 of individualities with PD have a first- degree relation who has the complaint, and 5 – 10 of people with PD are known to have forms of the complaint that do because of a mutation in one of several specific genes. Harbouring one of these gene mutations may not lead to the complaint; vulnerability factors put the existent at an increased threat [3], frequently in combination with other threat factors, which also affect age of onset, inflexibility and progression. At least 11 autosomal dominant and 9 autosomal sheepish gene mutations have been intertwined in the development of PD. The autosomal dominant genes include SNCA, PARK3, UCHL1, LRRK2, GIGYF2, HTRA2, EIF4G1, TMEM230, CHCHD2, RIC3, and VPS35. Autosomal sheepish genes include PRKN, PINK1, PARK7, ATP13A2, PLA2G6, FBXO7, DNAJC6, SYNJ1, and VPS13C. Some genes are X-linked or have unknown heritage pattern; those include PARK10, PARK12, and PARK16. A 22q11 omission is also known to be associated with PD [4]. An autosomal dominant form has been associated with mutations in the LRP10 gene.


Exposure to fungicides and a history of head injury have each been linked with PD, but the pitfalls are modest. No way drinking caffeinated potables is also associated with small increases in threat of developing PD. Some poisons can beget Parkinsonism, including manganese and carbon disulfide.

Medical medicines intertwined in cases of Parkinsonism. Medicine- convinced Parkinsonism is typically reversible by stopping the offending agent [5], similar as phenothiazines (chlorpromazine, promazine, etc.); but yrophenones (haloperidol, benperidol, etc.); metoclopramide and Tetrabenazine. 1-Methyl (MPTP) is a medicine known for causing unrecoverable Parkinsonism that’s generally used in beast- model exploration.

Low attention of urate in the blood is associated with an increased threat of PD.


  1. De Lau LM, Breteler MM (2006) Epidemiology of Parkinson's disease. Lancet Neurol 5:525-35.
  2. Indexed at, Google Scholar, Crossref

  3. Lill CM, Klein C (2017) Epidemiology and causes of Parkinson's disease. Nervenarzt 88:345-355.
  4. Indexed at, Google Scholar, Crossref

  5. Balestrino R, Schapira AHV (2020) Parkinson disease. Eur J Neurol 27:27-42.
  6. Indexed at, Google Scholar, Crossref

  7. Lew M (2007) Overview of Parkinson's disease. Pharmacotherapy 27:155S-160S.
  8. Indexed at, Google Scholar, Crossref

  9. Rose O (2016) Parkinson’s disease: Basic knowledge. Med Monatsschr Pharm 39:277-281.
  10. Indexed at, Google Scholar

Citation: Radhakrishnan R (2022) Causes of Parkinson’s Disease. Neurol Clin Therapeut J 6: 122. DOI: 10.4172/nctj.1000122

Copyright: © 2022 Radhakrishnan R. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Post Your Comment Citation
Share This Article
Recommended Conferences

36th European Neurology Congress 2023

Amsterdam, Netherlands Antilles

9th Annual Neurologists and Neurosurgeons Meet

Toronto, Canada
Article Usage
  • Total views: 420
  • [From(publication date): 0-2022 - Mar 27, 2023]
  • Breakdown by view type
  • HTML page views: 198
  • PDF downloads: 222

Post your comment

captcha   Reload  Can't read the image? click here to refresh
Peer Reviewed Journals

Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals

Clinical & Medical Journals

Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar