Journal of Obesity & Weight Loss Therapy
Open Access

Diet-induced thermogenesis; Obesity; Energy expenditure; Brown adipose tissue; Metabolism; Macronutrients; Exercise; Thyroid hormones; Gut microbiota; Weight management

Introduction

Diet-induced thermogenesis, a key component of daily energy expenditure, represents the energy required to process food for digestion, absorption, and storage. What this really means is that our bodies burn calories simply by eating. This article emphasizes its significant, often overlooked role in preventing and treating obesity, suggesting that boosting DIT could be a viable strategy to manage body weight [1].

Brown adipose tissue (BAT) plays a crucial role in thermogenesis, burning calories to produce heat rather than storing them. This review clarifies the mechanisms by which BAT contributes to human energy metabolism, including its activation by diet-induced thermogenesis. Understanding this process could open doors to new strategies for metabolic health [2].

This systematic review and meta-analysis investigated how different macronutrient compositions influence diet-induced thermogenesis in healthy adults. The findings show that protein generally elicits a higher thermic effect compared to carbohydrates and fats, providing crucial insights into dietary strategies for optimizing energy expenditure and body weight management. This work highlights the importance of specific dietary choices [3].

This review explores the complex interplay between exercise, obesity, and dietary thermogenesis. It highlights how regular physical activity can modulate DIT, potentially enhancing the metabolic response to food intake and contributing to improved weight management. Understanding these interrelationships is key to developing integrated strategies for combating obesity [4].

Thyroid hormones are well-known regulators of metabolism and thermogenesis. This article offers a fresh look at their role in diet-induced thermogenesis, suggesting that variations in thyroid hormone activity can significantly influence how the body processes food and expends energy. This perspective could lead to better understanding of individual metabolic differences [5].

Individuals show significant variation in their diet-induced thermogenesis responses, which can influence susceptibility to weight gain or loss. This critical review examines the factors contributing to this inter-individual variability, including genetics, gut microbiota, and lifestyle, offering insights into personalized nutrition strategies. It really highlights why what works for one person might not work for another [6].

This article explores the intricate relationship between metabolic syndrome, diet-induced thermogenesis, and the gut microbiota. It demonstrates how dysregulation of DIT and imbalances in gut flora can contribute to metabolic disorders, suggesting that targeting these factors could offer therapeutic avenues for metabolic syndrome. What this really means is that our gut health directly impacts how efficiently we burn calories from food [7].

This narrative review examines the current understanding of brown adipose tissue activity and its contribution to diet-induced thermogenesis in human adults. It highlights how BAT's capacity to expend energy through heat production is a significant factor in metabolic health and offers potential targets for interventions to combat obesity [8].

Capsaicin, the active compound in chili peppers, has garnered attention for its potential to boost metabolism. This systematic review and meta-analysis consolidates evidence on how capsaicin influences diet-induced thermogenesis and overall energy expenditure. The findings suggest that incorporating capsaicin into the diet can modestly increase calorie burning, offering a natural way to support weight management efforts [9].

Accurately measuring diet-induced thermogenesis is fundamental for research and clinical applications. This review delves into current practices and future directions for assessing DIT using indirect calorimetry, the gold standard method. It discusses methodological challenges and considerations, which is crucial for ensuring reliable and comparable results across studies [10].

Description

Diet-induced thermogenesis (DIT) is recognized as a vital component of daily energy expenditure, representing the energy the body expends to digest, absorb, and store food. Essentially, our bodies burn calories simply through the act of eating, a process which holds significant, though often overlooked, potential in the prevention and treatment of obesity. Strategies aimed at boosting DIT could offer a viable approach for managing body weight effectively [1].

Central to thermogenesis is the role of Brown Adipose Tissue (BAT), which actively burns calories to generate heat rather than storing energy as fat. This vital mechanism contributes substantially to human energy metabolism and is notably activated by diet-induced thermogenesis itself. Understanding the full extent of BAT's activity in adult humans and its contribution to DIT is key to developing new strategies for metabolic health, potentially offering targets for combating obesity [2, 8]. Furthermore, thyroid hormones, established regulators of metabolism, significantly influence DIT. Variations in their activity can impact how the body processes food and expends energy, shedding light on individual metabolic differences and how different people respond to dietary intake [5].

The composition of one's diet plays a crucial role in determining DIT. Research consistently shows that macronutrient ratios, particularly a higher protein intake, elicit a greater thermic effect compared to carbohydrates and fats. This provides important insights into optimizing energy expenditure through specific dietary choices for weight management [3]. Beyond diet, regular physical activity is another critical modulator of DIT. Exercise can enhance the metabolic response to food intake, contributing positively to weight management efforts. A comprehensive understanding of these interrelationships is essential for crafting integrated strategies to combat obesity [4]. Interestingly, compounds like capsaicin, present in chili peppers, have also been observed to modestly increase DIT and overall energy expenditure, suggesting natural dietary inclusions can support metabolism [9].

Significant inter-individual variability exists in DIT responses, which profoundly influences a person's susceptibility to weight gain or loss. This variability is complex, stemming from factors such as genetics, gut microbiota, and broader lifestyle choices, thereby emphasizing the necessity for personalized nutrition approaches. The intricate interplay between metabolic syndrome, DIT, and the gut microbiota further reveals that dysregulation in DIT alongside imbalances in gut flora can contribute to various metabolic disorders. This implies that gut health directly impacts the efficiency with which calories are burned from food, offering potential therapeutic avenues for metabolic syndrome [6, 7].

For research and clinical applications, the accurate measurement of DIT is paramount. Indirect calorimetry stands as the gold standard method, but its implementation involves various methodological challenges and considerations. Addressing these is crucial for ensuring reliable and comparable results across different studies, paving the way for more precise understanding and intervention strategies in metabolism and weight management [10].

Conclusion

Diet-induced thermogenesis (DIT) represents the energy expended by the body to process food, a critical yet often overlooked component of daily energy expenditure. Boosting DIT holds promise as a strategy for preventing and treating obesity. Brown Adipose Tissue (BAT) significantly contributes to thermogenesis by burning calories for heat, a process activated by DIT and important for metabolic health. Research indicates that the macronutrient composition of a diet influences DIT, with protein generally eliciting a higher thermic effect compared to carbohydrates and fats, providing insights for optimizing energy expenditure. Beyond diet, regular physical activity can modulate DIT, potentially enhancing the metabolic response to food intake and aiding weight management. Thyroid hormones also play a role, with variations in their activity influencing how the body processes food and expends energy, contributing to individual metabolic differences. This highlights significant inter-individual variability in DIT responses, which is shaped by genetics, gut microbiota, and lifestyle, underscoring the need for personalized nutrition strategies. The intricate relationship between metabolic syndrome, DIT, and gut microbiota further suggests that gut health directly impacts calorie burning efficiency. Natural compounds like capsaicin, found in chili peppers, have been shown to modestly increase DIT and overall energy expenditure, offering a natural support for weight management. Accurate measurement of DIT, typically through indirect calorimetry, is fundamental for both research and clinical applications, despite facing methodological challenges. Understanding these diverse factors and their interplay is crucial for developing integrated and effective approaches to manage body weight and improve metabolic health.

References

1. Molly Q, Pradeep J, Cristina B (2023) Diet-induced thermogenesis: A forgotten energy expenditure component for obesity prevention and treatment.J Clin Invest 133:e167399.

   Indexed at, Google Scholar, Crossref

2. Elias R, Merja A, Peter A (2021) Brown adipose tissue, thermogenesis and the regulation of human energy metabolism.Nat Rev Endocrinol 17:35-49.

   Indexed at, Google Scholar, Crossref

3. Hui S, Peng P, Xiaoyu Z (2023) Macronutrient composition of diet and its effect on diet-induced thermogenesis in healthy adults: A systematic review and meta-analysis of randomized controlled trials.Obes Rev 24:e13593.

   Indexed at, Google Scholar, Crossref

4. Minjung K, Pilkyu S, Youngran K (2020) Exercise, obesity, and dietary thermogenesis: A review of the interrelationships.J Exerc Rehabil 16:289-296.

   Indexed at, Google Scholar, Crossref

5. Georgi G, Peter T, George K (2022) Thyroid hormones and thermogenesis: A new perspective on old players.Exp Clin Endocrinol Diabetes 130:630-639.

   Indexed at, Google Scholar, Crossref

6. Ellen EB, Patrick S, Laura MvE (2021) Inter-individual variability in diet-induced thermogenesis: A critical review.Obes Rev 22:e13158.

   Indexed at, Google Scholar, Crossref

7. Yang C, Lei Z, Yan L (2022) Metabolic syndrome, diet-induced thermogenesis and the microbiota: A complex interplay.Front Cell Dev Biol 10:902871.

   Indexed at, Google Scholar, Crossref

8. Carlijn vdB, Lisanne S, Klaas RW (2023) Brown adipose tissue activity and diet-induced thermogenesis in human adults: A narrative review.Obes Rev 24:e13508.

   Indexed at, Google Scholar, Crossref

9. Yifan W, Jing Y, Hong W (2023) The role of capsaicin in energy metabolism and thermogenesis: A systematic review and meta-analysis.Food Sci Nutr 11:5464-5474.

   Indexed at, Google Scholar, Crossref

10. Madhuri SS, Ashish DD, Sanjeev BK (2020) Indirect calorimetry for the assessment of diet-induced thermogenesis: A review of current practices and future directions.J Clin Diag Res 14:LE01-LE05.

    Indexed at, Google Scholar, Crossref