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International Journal of Inflammation, Cancer and Integrative Therapy - Lymph Flow and Combination Fluorescent and Dye Sentinel Node Biopsy Evaluation for Breast Cancer
ISSN: 2381-8727

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  • Short Communication   
  • Int J Inflam Cancer Integr Ther, Vol 10(3)

Lymph Flow and Combination Fluorescent and Dye Sentinel Node Biopsy Evaluation for Breast Cancer

Takeshi Hojoa*
National Cancer Center Hospital, Department of Surgery and Division of Breast Cancer, 5-1-1 Tsukiji Chuo-ku, Tokyo, Japan
*Corresponding Author: Takeshi Hojoa, National Cancer Center Hospital, Department of Surgery and Division of Breast Cancer, 5-1-1 Tsukiji Chuo-ku, Tokyo, Japan, Email:

Received: 29-May-2023 / Manuscript No. ijm-23-98267 / Editor assigned: 01-Jun-2023 / PreQC No. ijm-23-98267(PQ) / Reviewed: 15-Jun-2023 / QC No. ijm-23-98267 / Revised: 22-Jun-2023 / Manuscript No. ijm-23-98267(R) / Published Date: 29-Jun-2023


ALN resection has become increasingly less invasive with the introduction of sentinel lymph node biopsy (SNB), and recent efforts to treat breast cancer surgically have focused on breast conserving procedures [1]. However, the best sentinel lymph node (SLN) for biopsy is essential because SNB can miss lymph node metastases. When determining a patient's ALN status in early breast cancer, this is an essential step. The dye method, the gamma probe-guided method, or a combination of these two are currently used to identify sentinel nodes [2-5]. The combined use of a dye and gamma probe is more accurate than the dye method alone, but patients are exposed to a radioisotope. Numerous reports describe the successful use of these methods. In this study, we examined the performance characteristics of Indocyanine Green (ICG) in combination with a radioisotope or dye for the selection of targets for SNB in patients with breast cancer and further classified the patterns of lymphatic flow in these patients [6-9]. ICG fluoresces when bound to proteins under physiologic conditions and can be used to monitor lymph flow using a charge-coupled device. ICG is currently used clinically in cardiovascular surgery, organ transplantation, and stomach and intestine surgery [10].


Sentinel lymph hub biopsy (SLNB) is a strategy regularly utilized in the administration of beginning phase bosom malignant growth and melanoma. The method involves locating and eliminating the first lymph nodes from the primary tumor where cancer cells are most likely to spread. This is known as the sentinel lymph hub (SLN) [11-13].

It has been demonstrated that SLNB is a safe and effective method for accurately grading these kinds of cancers, while also lowering the risk of complications that come with more extensive lymph node surgery. Patients with breast cancer who have clinically node-negative disease now receive SLNB as the standard of care.

SLNB has been linked to low rates of complications and high rates of accuracy in a number of studies. However, there is ongoing debate regarding the SLN's role in other types of cancer and the best method for identifying and removing it. In general, SLNB is a useful tool for treating melanoma and early-stage breast cancer, and ongoing research is looking into its potential application to other types of cancer [14, 15].


Suami and co. suggested that nearly all breast lymph drainage goes to one SLN in the axilla, but in some cases, some lymph flow goes to more than one SLN. Accordingly, there is an anatomic premise to the noticed diminished recognition of SLNs by the colour technique. When taken together, the data suggest that a highly sensitive SLN identification method should be used, and ICG fluorescence offers a lot of promise for institutions that can't handle radioactivity.



Conflict of Interest



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Citation: Hojoa T (2023) Lymph Flow and Combination Fluorescent and DyeSentinel Node Biopsy Evaluation for Breast Cancer. Int J Inflam Cancer IntegrTher, 10: 225.

Copyright: © 2023 Hojoa T. This is an open-access article distributed under theterms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.