World Journal of Pharmacology and Toxicology
Open Access

Microplastics; Nanoplastics; Human health; Toxicity; Oxidative stress; Inflammation; Endocrine disruption; Genotoxicity

Introduction

Microplastics (MPs) are emerging pollutants of global concern, infiltrating ecosystems and posing potential risks to human health. Defined as plastic particles smaller than 5 mm, microplastics originate from various sources, including the breakdown of larger plastic debris, synthetic fibers from textiles, and microbeads used in personal care products. These particles are now ubiquitous in air, water, and food supplies, leading to widespread human exposure through ingestion, inhalation, and dermal contact [1]. Recent studies have raised significant concerns regarding the potential toxicity of microplastics. Due to their small size and persistent nature, MPs can accumulate in the gastrointestinal and respiratory systems, where they may trigger oxidative stress, inflammation, and immune system dysregulation. Furthermore, microplastics serve as carriers for toxic substances such as heavy metals, persistent organic pollutants (POPs), and pathogenic microorganisms, exacerbating their harmful effects. The presence of nanoplastics smaller fragments of MPs raises additional concerns, as their increased bioavailability allows for easier cellular penetration and potential interactions with biological processes at the molecular level [2].

Microplastic exposure has been linked to a range of adverse health effects, including endocrine disruption, metabolic disorders, neurotoxicity, and carcinogenicity. However, the full scope of their impact on human health remains unclear due to the complexity of exposure pathways, variations in microplastic composition, and the long-term nature of their effects. Current research is focused on understanding the mechanisms of microplastic-induced toxicity, identifying biomarkers of exposure, and assessing potential health risks through epidemiological and toxicological studies [3].

Despite increasing awareness, regulatory measures addressing microplastic contamination and human exposure remain limited. More comprehensive risk assessment frameworks, improved detection techniques, and policy interventions are urgently needed to mitigate the potential health risks associated with microplastics. This review explores the latest findings on microplastic toxicity, examines its implications for human health, and discusses future directions for research and regulation [4].

Discussion

The widespread presence of microplastics (MPs) in the environment and their increasing detection in human tissues raise critical concerns regarding their potential toxicity. While research on microplastic toxicity is still evolving, existing evidence suggests that these pollutants can induce adverse biological effects through various mechanisms, including oxidative stress, inflammation, endocrine disruption, and genotoxicity. This discussion explores the pathways of human exposure, the biological mechanisms underlying microplastic toxicity, and the broader implications for public health [5].

Pathways of Human Exposure

Humans are exposed to microplastics primarily through ingestion, inhalation, and dermal contact.

Ingestion: MPs have been detected in drinking water, seafood, salt, fruits, vegetables, and processed foods. Their accumulation in the gastrointestinal (GI) tract may disrupt gut microbiota, impair nutrient absorption, and induce local inflammation [6].

Inhalation: Airborne MPs from industrial emissions, synthetic textiles, and household dust can be inhaled, leading to potential respiratory toxicity, including lung inflammation and oxidative damage.

Dermal Contact: While skin penetration of MPs is less studied, concerns exist regarding their potential absorption, particularly for nanoplastics, which can infiltrate deeper skin layers and possibly enter the circulatory system [7].

Biological Mechanisms of Microplastic Toxicity

Oxidative Stress and Inflammation: MPs can generate reactive oxygen species (ROS), leading to oxidative damage in cells and tissues. Prolonged oxidative stress can activate inflammatory pathways, contributing to chronic inflammation and tissue damage, particularly in the gut and lungs.

Endocrine Disruption: Microplastics often contain or adsorb endocrine-disrupting chemicals (EDCs), such as bisphenol A (BPA) and phthalates. These chemicals can interfere with hormonal balance, potentially contributing to reproductive disorders, metabolic diseases, and developmental abnormalities [8].

Genotoxicity and Carcinogenicity: Studies suggest that MPs may induce DNA damage through direct interaction with genetic material or through ROS-mediated mechanisms. Long-term exposure could potentially increase the risk of mutations and carcinogenesis.

Neurotoxicity: Emerging research indicates that MPs and associated contaminants can cross the blood-brain barrier, leading to neuroinflammation, altered neurotransmitter function, and cognitive impairments. Further studies are needed to determine the extent of their neurotoxic effects [9].

Implications for Human Health and Public Policy

The potential health risks associated with microplastics highlight the urgent need for regulatory action and further research. However, several challenges remain:

Lack of Standardized Detection Methods: There is no universally accepted method for quantifying MPs in biological samples, making it difficult to assess exposure levels accurately.

Unclear Long-Term Effects: Many studies focus on short-term toxicity, but the long-term effects of chronic microplastic exposure remain largely unknown.

Regulatory Gaps: Despite growing concerns, existing regulations on microplastic pollution primarily focus on environmental contamination rather than direct human health impacts. More stringent policies are needed to reduce plastic pollution at the source and minimize human exposure [10].

Conclusion

Microplastics represent a significant emerging toxicological concern with potential long-term implications for human health. While current evidence suggests that MPs can induce oxidative stress, inflammation, and endocrine disruption, further research is needed to establish definitive causal links and risk thresholds. Future studies should focus on developing standardized exposure assessment methods, identifying biomarkers of microplastic toxicity, and implementing regulatory measures to mitigate human exposure. Addressing this issue requires a multidisciplinary approach involving toxicologists, environmental scientists, policymakers, and public health professionals.

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