Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar


Missed Diagnosis of Cancer in Critically Ill Patients: A Single-Center Experience
ISSN: 2161-0681
Journal of Clinical & Experimental Pathology

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business
  • Research Article   
  • J Clin Exp Pathol 2016, Vol 6(6): 299
  • DOI: 10.4172/2161-0681.1000299

Missed Diagnosis of Cancer in Critically Ill Patients: A Single-Center Experience

Berlot G1*, Calderan C1, Moro V1, Bussani R2 and Zandonà L2
1Department of Anaesthesia and Intensive Care Medicine, University of Trieste, Trieste, Italy
2Department of Pathology, University of Trieste, Trieste, Italy
*Corresponding Author: Berlot G, Department of Anaesthesia and Intensive Care, Cattinara Hospital, Strada di Fiume 447, Trieste, 34149, Italy, Tel: +39040-3994540; +39040-912278, Email:

Received: 15-Nov-2016 / Accepted Date: 19-Nov-2016 / Published Date: 22-Nov-2016 DOI: 10.4172/2161-0681.1000299


Purpose and methods: In order to evaluate the rate of missed diagnoses (MD) of tumors in critically ill patients died in our Intensive Care Unit (ICU) and correlate them with the outcome, all the autopsy records from January 1st, 1996 and December 31st, 2014 have been reviewed. When the tumor was not diagnosed during the admission but discovered only at the post-mortem examination, the effect of the MD on the outcome was classified according to the Goldman’s criteria.

Results: A total of, 1045 autopsies were examined; a solid or hematological cancer was discovered in 74 cases (7%, 50 M, 24 F, age 75.5, IQR 29-90 years). Major discrepancies occurred in 42 patients, but only in one of them (2.4%) a class 1 error was identified; in the other cases the MD did not influence the outcome (class 2 errors) due to the underlying conditions determining the ICU admission and/or the very short length of stay in the ICU; for another 32 patients the MD were considered without clinical relevance.

Conclusions: In our experience, autopsy remains an extremely valuable tool to detect MD and to improve the clinical and diagnostic procedures.

Keywords: Autopsy; Missed diagnosis; Intensive care unit; Tumors


Several studies demonstrated that the rate of diagnostic discrepancies discovered at the autopsy is still high in patients dying both in the regular wards and in the Intensive Care Unit (ICU), ranging from 5 to 40% and from 7 to 32%, respectively [1]. Despite a worldwide decrease in their numbers, which started several decades ago, autopsies represent a valuable tool to improve the clinical practice primarily by enlightening possible breakdowns of the diagnostic procedures and/or a wrong interpretation of the available informations [2,3]. This particularly applies to ICU patients who are at risk of missed diagnosis (MD) primarily because of the relative lack of specificity of symptoms such as fever, tachycardia, arterial hypotension and disturbances of the consciousness; moreover, the often rapidly evolving clinical course can prevent clinicians from a diagnostic workup not immediately targeted on the life-threatening conditions requiring the admission. A number of investigations demonstrated that infections and cardio-respiratory diseases, including pulmonary embolisms and myocardial infarctions account for a substantial rate of MD in this population, with variable effects on the outcome ranging from negligible to substantially deadly [1,4-7]. Although the occurrence of autopsy-discovered malignancies is less common [8], yet they can represent as many as 10% of cases [9,10] in patients admitted for reasons other than tumors. However, independently from their rate of occurrence, the ante-mortem diagnosis of neoplastic diseases in critically ill patients appears relevant for two opposite reasons. On one hand, it could identify acutely ill patients admitted to the ICU who might take some advantage from anti-tumor treatments once the acute phase is over [11]; actually, Taccone et al. [12] demonstrated that the outcome of critically ill patients with already diagnosed solid cancer is similar to that of subjects without cancer.

On the other hand, it could prevent the implementation of costly life-extending procedures which often are associated with heavy side effects but which are devoid of any significant effect on the survival of patients with more advanced and/or metastatic forms, thus leaving space to palliative therapies.

We reviewed both the autopsy and the clinical records of all patients died in our ICU with the double aim (a) to identify the patients died in our ICU in whom a neoplastic disease was discovered only at the postmortem examination; and (b) to correlate this MD with the outcome.

Patients and Methods

We retrospectively reviewed the autopsy records of the patients dead in our 13-bed general ICU between January 1st, 1996 and December 31st, 2014. The consent of the local ethical committee was deemed unnecessary because the study was retrospective, did not imply any intervention and the privacy was secured. Our medical-surgical ICU is located inside a 750-bed university hospital, admits about 1000 patients/year coming both from the emergency department and from the regular wards, and has a 23% mortality rate.

For our study we did not adopted any selection criteria. We did not include in the study (a) patients dying in the coronary care unit or cardiac surgery ICU because they are treated in other wards; (b) obstetric and pediatric patients, as they are treated in another hospital; and (c) patients who died after trauma because, according to the current Italian Law, legal autopsy findings cannot be disclosed to the physicians in charge.

All patients were intubated and mechanically ventilated throughout their ICU admission; sepsis and sepsis-related conditions, including severe sepsis and septic shock, were treated according to the current guidelines [13]. All patients with cardiac arrest were admitted directly from the ER.

The university hospital in which our ICU is situated has an autopsy rate of 48%, which remained stable over the past two decades. The autopsies were performed by a single experienced pathologist with a peculiar expertise in critically ill patients (RB).

All the autoptical records were screened and when a solid or hematologic tumor was found, the relative discharge diagnosis was cross-checked; when the neoplasm was not mentioned, the corresponding medical record was retrieved and a number of data were collected, including (a) all the relevant personal and clinical informations including age, gender, history, cause of admission, length of stay in ICU (LOSICU), SOFA score the day of admission and the radiologic investigations performed; and (b) the type and location of the tumor discovered at the autopsy.

Each positive case was discussed by all the authors and the MD were classified according the Goldman’s criteria in [14]: major MD with or without effects on the management and the outcome are included in Class 1 and 2, respectively, whereas Class 3 and 4 are minor MD (Table 1).

Category Class Definitions
Major Discrepancies 1 A correct diagnosis and treatment could have changed the outcome
2 A correct diagnosis and treatment could NOT have changed the outcome
Minor Discrepancy 3 Missed terminal disease unrelated with the cause of death
4 Other missed diagnosis unrelated to death
No discrepancies 5 No missed diagnosis
Not classifiable 6 Patients dead immediately after the admission, diagnostic workup incomplete or absent, autopsy inconclusive

Table 1: Classification of diagnostic discrepancies according to their effect on the outcome.

We used the free software R for statistical analysis (R Development Core Team, R Foundation for Statistical computing, Vienna, Austria 2008). The statistical analysis was performed with the Fisher’s exact ttest; a p<0.05 was considered statistically significant.


In the considered period, 1045 autopsies were performed on patients died in our ICU (Figure 1).


Figure 1: Distribution of tumors.

Overall, a solid or hematologic cancer was discovered in 74 patients (7.0%, 50 M, 24 F, age 75.5, IQR 29-90 years). In no case a suspected diagnosis of tumor was reported on the medical records of the wards where patients were initially admitted. Albeit virtually every organ and system was involved, the missed solid tumors were located prevalently in the lung, digestive tract, prostate and kidney. During autopsy, in the 29.7% of patients with solid tumor were found a regional lymph nodes involvement and distant metastasis; regarding the hematologic cancers, in the 63.6% of cases were found an infiltration and invasion of the bone marrow, spleen, liver and lymph nodes. Patients with MD were subdivided into seven categories according to the causes of ICU admission. Overall, the rate of major MD was 58% for patients admitted due to respiratory failure, 83% for severe sepsis/septic shock, 38% for postoperative complications, 45% for haemorrhagic/ cardiogenic shock, 71% for cardiac arrest and none for intra-cerebral hemorrhage (Figure 2).


Figure 2: Causes of ICU admission. Y-axis: no. of patients.

The autoptical results, class of MD, radiological investigations and findings and LOSICU are reported separately for each category apart cerebral hemorrhage for which no major MD were found (Table 2).

Goldman’s class Category Total no. Solid tumors Hematological tumors Multiple tumors
1 Major MD 1 1 0 0
2 41 30 9 2
3 Minor MD 32 30 0 2
4 0 0 0 0

Table 2: Impact of MD (missed diagnoses) of tumor on the outcome.

Forty-five patients (61%) had a LOSICU<24 hours; their distribution is uneven, ranging from 37% of those admitted for respiratory failure to 100% of those admitted for haemorrhagic or cardiogenic shock. Two patients (10%) admitted for respiratory failure, other two (17%) of those admitted for severe sepsis or septic shock and one admitted for intra-cerebral hemorrhage had a LOSICU>14 days.

We identified a Class 1 MD in one case (2.4%). In the other cases the severity of the conditions determining the ICU admission and/or the short LOSICU justified both the poor outcome and the lack of a more in-depth diagnostic workup; other MD had no relationship with the clinical course or constituted only incidental findings (Tables 3 and 4).

No. Cancer Histological type Radiologic investigations Radiologic findings Goldman’s class LOSICU SOFA score (1st day)
1 Lung Adenocarcinoma CRX Negative 2 5 days 11
2 Bladder Urothelial carcinoma CT abdomen Negative 3 12 days 10
3 Thyroid Papillary carcinoma Head and Neck CT Enlarged laterocervical nodes 3 8 days 8
4 Lung Adenocarcinoma CRX ARDS 2 11 days 5
5 Lymphoma T-cell lymphoma CRX,
abdominal US
Negative 2 <24 hours 10
6 Colon Adenocarcinoma CT abdomen Negative 3 <24 hours 16
7 Lymphoma B-cell non Hodgkin lymphoma CRX Negative 2 5 days 5
8 Lung Adenocarcinoma CRX Single pulmonary opacity 2 11 days 4
9 Stomach Adenocarcinoma CRX Negative 2 1 day 9
10 Colon-prostate Both adenocarcinoma CRX Negative 3 <24 hours 9
11 Lung Adenocarcinoma CRX Mediastinal widening 2 1 day 12
12 Colon Adenocarcinoma Abdominal US Negative 3 <24 hours 8
13 Lung Adenocarcinoma CRX Single pulmonary opacity 1 53 days 5
14 Lung Adenocarcinoma CRX Pleural effusion 2 <24 hours 9
15 Lung Adenocarcinoma None N.A. 2 <24 hours 5
16 Kidney Renal cell carcinoma Abdominal US Negative 3 5 days 3
17 Pancreas Adenocarcinoma CRX Right lung opacity/ARDS 2 <24 hours 11
18 Kidney Renal cell carcinoma CRX ARDS 3 10 days 10
19 Thyroid Papillary carcinoma CRX Multiple lung opacities 3 30 days 9

Table 3: Radiologic investigations, LOSICU, and postmortem findings in patients admitted due to respiratory failure. Legend: CRX: plain chest Xray; US: ultrasonography; ARDS: acute respiratory distress syndrome; N.A.: not applicable.

No. Cancer Histological type Radiologic investigations Radiologic
LOSICU SOFA score (1st day)
1 Leukemia AML CRX Negative 2 <24 hours 12
2 Lung Adenocarcinoma Lung CT Massive pulmonary opacity 2 <24 hours 5
3 Thyroid Papillary carcinoma CRX, abdominal CT Negative 3 22 days 9
4 Pancreas Adenocarcinoma Abdominal  US Negative 2 <24 hours 12
5 Stomach and pancreas Mucinous adenocarcinoma CRX,  abdominal and lung CT Negative 2 5 days 10
6 Leukemia AML Abdominal and lung CT Negative 2 <24 hours 10
7 Leukemia AML RX, abdominal CT Negative 2 <24 hours 15
8 Biliary tract Cholangiocarcinoma Percutaneous colangiography Negative 2 20 days 6
9 Colon and rectum Adenocarcinoma CRX Negative 3 6 days 3
10 Leukemia AML None N.A. 2 <24 hours 9
11 Leukemia ALL CRX Negative 2 <24 hours 15
12 Liver Hepatocellular carcinoma Abdominal CT Liver infarction 2 <24 hours 13

Table 4: Radiologic investigations and findings, LOSICU, and postmortem findings in patients admitted due to severe sepsis and septic shock. Legend: CRX: plain chest X-ray; US: ultrasonography; N.A. not applicable.


There is an on-going debate between supporters of autopsy and others who consider the post mortem investigation somehow outdated. The former advocate its use mainly to verify the overall diagnostic and therapeutic appropriateness and thus to reduce avoidable deaths by identifying MD which could have influence negatively the outcome both in patients died in the regular wards and in the ICU [14-16,9], whereas the latter claim that its value is reduced, but not totally abolished, in the era of unrelenting advances of the imaging techniques [17,18]. Besides these, in the past years other factors contributed to determine a worldwide decrease in the rate of autopsies in patients died in the hospital, including poor training of pathologists in its execution, costs and the fear of litigation (Tables 5-7) [19,20].

No. Cancer Histological type Radiologic investigations Radiologic
LOSICU SOFA score (1st day)
1 Kidney Renal cell carcinoma Abdominal CT Negative 3 10
2 Kidney Renal cell carcinoma Abdominal CT Benign renal cyst 3 5 days 10
3 Pancreas Mucinous adenocarcinoma Abdominal CT Pancreatic pseudo cyst/abscess 2 6
4 Kidney Renal cell carcinoma Head CT Negative 3 5 days 7
5 Stomach Mucinous adenocarcinoma CRX Negative 2 10
6 Colon rectum Adenocarcinoma Abdominal CT Negative 3 4 days 15
7 Colon rectum Adenocarcinoma CRX Negative 2 3 days 9
8 Colon rectum Adenocarcinoma None N.A. 3 4
9 Kidney Renal cell carcinoma Abdominal CT Benign renal cyst 3 12 days 9
10 Uterus ovary Adenocarcinoma CRX Negative 3 4
11 Colon rectum Adenocarcinoma Abdominal CT Negative 2 7
12 Lung Biphasic blastoma CRX Negative 3 16
13 Lung Squamous cell carcinoma CRX Negative 2 4

Table 5: Radiologic investigations and findings, LOSICU, and autopsy results in patients admitted for postoperative complications. Legend: CRX: plain chest X-ray; N.A. not applicable.

Hemorrhagic shock No. Cancer Histological type Radiologic investigations Radiologic
LOSICU SOFA score (1st day)
1 Kidney Renal cell carcinoma None N.A. 3 5
2 Leukemia, lung AML, Squamous cell carcinoma None N.A. 2 5
3 Leukemia AML None N.A. 2 14
4 Prostate Adenocarcinoma None N.A. 2 15
5 Liver Hepatocellular carcinoma CRX Negative 2 7
Cardiogenic shock 6 Adrenal gland Adenocarcinoma None N.A. 3 5
7 Prostate Adenocarcinoma None N.A. 3 12
8 Stomach Adenocarcinoma EGDS Negative 3 7
9 Uterus, ovary Adenocarcinoma None N.A. 3 6
10 Colon, rectum Adenocarcinoma None N.A. 3 6
11 Liver Hepatocellular carcinoma EGDS Negative 2 7

Table 6: Radiologic investigations, LOSICU, and postmortem findings in patients admitted due to hemorrhagic and cardiogenic shock. Legend: CRX: chest X-ray; EGDS. Esophagogastroduodenalscopy, N.A. not applicable.

No. Cancer Histological type Radiologic investigations Radiologic findings Goldman’s class LOSICU SOFA score (1st day)
1 Colon rectum Adenocarcinoma None N.A. 2 6
2 Lung. Myeloma Neuroendocrine cell carcinoma, myeloma CRX Pulmonary opacity
3 5 days 7
3 Colon rectum Adenocarcinoma None N.A. 2 9
4 Lung Adenocarcinoma Lung CT Pulmonary abscess 2 2 days 14
5 Leukemia AML CRX, lung CT Negative 2 7 days 4
6 Kidney Renal cell carcinoma None N.A. 3 10
7 Lung Adenocarcinoma CRX Pulmonary opacity
2 7
8 Liver, colon rectum Hepatocellular carcinoma, adenocarcinoma CRX Negative 2 7
9 Colon rectum Adenocarcinoma CRX, abdominal CT Negative 2 11 days 5
10 Pancreas Adenocarcinoma None N.A. 2 3
11 Colon Adenocarcinoma None N.A. 2 7
12 Prostate Adenocarcinoma CRX Negative 3 3 days 10
13 Prostate Adenocarcinoma CRX Negative 3 3
14 Prostate Adenocarcinoma Abdominal RX Negative 2 2

Table 7: Radiologic investigations, LOSICU, and postmortem findings in patients admitted due to cardiac arrest. Legend: CRX: chest X-ray; N.A. not applicable.

Actually, even if some investigators demonstrated that in patients admitted to regular wards the occurrence of major MD decreased along two or three decades [21,22], other studies showed that in patients died in the ICU the rate of potentially treatable conditions escaping to the clinical and radiologic investigations remains relatively high primarily because of the elevated lack of specificity of the symptoms prompting the ICU admission and to the rapidly evolving clinical conditions [1,9]. Moreover, it is likely that the already compromised conditions of critically ill patients could amplify the effects of some MD making them more vulnerable [23]. Although several investigations have been dedicated to the MD in patients died with already diagnosed malignancies [24,25] the issue of neoplastic diseases discovered only during the autopsy in ICU patients admitted for other reasons has not been specifically addressed. Yet we guess that this topic is relevant for a number of reasons, including the everadvancing age of critically ill patients with the subsequent risk of underlying tumors, their prolonged LOSICU [26] and the need for a correct triage aimed to restrict aggressive life-sustaining treatments to neoplastic patients who could realistically take advantage from them.

Our findings deserve some remarks

First, the overall rate of MD of tumors varies among different studies, ranging from<4% to 50% of the autopsies performed in patients died either in regular wards and in ICU [8,9,27]; it is arguable that our relatively low rate of MD could be at least partly related to the above-enlisted exclusion criteria which impeded us to know the results of the autopsies performed in other categories of critically ill patients.

Second, the Goldman’s classification is extremely useful but it does not take into consideration the length of stay, which is a rather important variable especially in patients with rapidly deteriorating conditions like many of those admitted in the ICU; as an example, by excluding patients with a LOSICU ≤ 24 hours from our study, the rate of MD of tumors would be almost halved (4%): actually, it is likely that in these cases the extremely brief LOSICU limited the diagnostic workup to those life-threatening conditions responsible of the admission. On the other hand, a prolonged LOS did not guarantee against the presence of major MD, as they were encountered also in chronic critically ill patients whose LOSICU exceeded two weeks.

Third, as far as the site of tumor is concerned, our results partly differ from that those reported by Grinberg et al. [28] who observed a similar rate of lung cancers but higher ones of pancreatic and liver cancers; however, dissimilarly from the overall distribution of tumors which approaches that recorded in Italy with an elevated incidence of lung, colon and prostate tumors [29], no case of breast cancer was observed in female patients; we hypothesize that this finding could be primarily attributable to the widespread campaigns of screening initiated many years ago and are actively on-going.

Fourth, the MD of lung cancer occurred notwithstanding virtually every patient with a LOSICU>24 hours and many of those with a LOSICU below this threshold underwent one or more chest radiograph (CRX) or chest CT scan due to the cause of ICU admission or to conditions occurred thereafter. Actually, despite the advances of the techniques, all radiological investigations have some inherent limitations: as far as the sensitivity of CRX outside the ICU is concerned, some investigators demonstrated that as many as 19% of early lung cancer are missed with the chest radiograph [30,31]; also the chest CT-scan is not flawless: Wichmann et al. [32] compared conventional vs. CT autopsies and demonstrated that, albeit medical autopsies are less sensitive to detect traumatic injuries, the opposite occurs for cancer. Other circumstances can further complicate the diagnosis in critically ill mechanically ventilated patients: actually, despite its widespread use, in ICU patients the CRX appears particularly at risk of misinterpretation since it is usually obtained with mobile radiographic devices in the frontal view, whereas the lateral view can enlighten abnormalities unrecognizable when only the anteroposterior film is achieved [30]. Moreover, with both the CRX and the CT scan the lung cancers can be misdiagnosed with different radiologic abnormalities more commonly encountered in mechanically ventilated critically ill patients, including pneumonia, ARDS and pleural effusions which can cover or mask the underlying neoplasm [33,34].

Fifth, we did not measure the blood concentration of specific tumor markers, including the α-fetoprotein, the carcino-embrional antigen etc. because their blood value by itself is not a specific or sensible indicator of tumor; moreover, in critically ill patients their elevation can be ascribed to factors other than neoplasms such as the systemic inflammatory response syndrome or sepsis and sepsis-derived conditions which affected most if not all the ICU patients [35]; the same consideration applies for the measurement of the mediators of inflammation, including the C-reactive protein and procalcitonin, although their elevation has been advocated as an early marker of still asymptomatic neoplasms [36]; actually, they were repeatedly measured during the LOSICU, and resulted constantly altered most likely due to the presence of infections and other conditions associate with the release of pro-inflammatory substances [37,38].

Sixth, in one case only the MD of lung tumor was considered a Class 1 error as it occurred in a patients with a prolonged LOSICU which should have prompted more in-depth clinical investigations; the other major discrepancies observed have been considered belonging to the Class 2 as they occurred in patients whose coexistent conditions leading to the ICU admission were so critical that a correct diagnosis and treatment of tumor could not have changed the outcome and/or the LOSICU has been extremely brief ; in the other cases the MD was considered unrelated to the cause of death and thus categorized as Class 3 and 4 errors. We are aware that this finding is in contrast with the rate of 8% of Class 1 errors reported by a recent meta-analysis but these major MD consists primarily in acute cardiac and respiratory conditions and not by tumors such as in the current study [39].

It is arguable that if some patients with Class 2 errors would have been discharged alive from the ICU further investigations performed in the admitting ward would have been able to identify the tumor.

Finally, independently from the continuous advances in the clinical and radiological investigations, MD still represents an entity hard to eliminate especially in patients, such as those admitted to the ICU, whose symptoms can be interpreted in many ways, ascribed to a number of different conditions and/or are rapidly evolving. In these circumstances, in our as well as in other’s experience, autopsy remain an essential tool either to verify the appropriateness of the procedures and to recognize the limitations of other diagnostic tools.


In patients died in our ICU for reasons other than a neoplastic disease, a solid or hematologic cancer was found in 7% of cases; 57% of these MD were classified as a major discrepancy. Although 61% of these subjects had short LOSICU, major MD were found even in patients with chronic critical diseases.


  1. Maris C, Martin B, Creteur J, Remmelink M, Piagnerelli M, et al. (2007) Comparison of clinical and post-mortem findings in intensive care unit patients. Virchows Arch 450: 329-333.
  2. Burton JL, Underwood J (2007) Clinical, educational, and epidemiological value of autopsy. Lancet 369: 1471-1480.
  3. van den Tweel JG, Wittekind C (2016) The medical autopsy as quality assurance tool in clinical medicine: dreams and realities. Virchows Arch 468: 75-81.
  4. Tejerina E, Esteban A, Fernández-Segoviano P, Frutos-Vivar F, Aramburu J, et al. (2010) Accuracy of clinical definitions of ventilator-associated pneumonia: comparison with autopsy findings. J Crit Care 25: 62-68.
  5. Berlot G, Vergolini A, Calderan C, Bussani R, Torelli L, et al. (2010) Acute myocardial infarction in non-cardiac critically ill patients: a clinical-pathological study. Monaldi Arch Chest Dis 74:164-71.
  6. Berlot G, Calderan C, Vergolini A,Bianchi M, VivianietM, et al. (2011) Pulmonary embolism in critically ill patients receiving antithrombotic prophylaxis: a clinical-pathologic study. J Crit Care 26: 28-33.
  7. Kuijpers CC, Fronczek J, van de Goot FR, Niessen HW, van Diest PJ, et al. (2014) The value of autopsies in the era of high-tech medicine: discrepant findings persist. J ClinPathol 67: 512-519.
  8. Tejerina E, Esteban A, Fernández-Segoviano P, María Rodríguez-Barbero J, Gordo F, et al. (2012) Clinical diagnoses and autopsy findings: discrepancies in critically ill patients. Crit Care Med 40: 842-846.
  9. Perkins GD, McAuley DF, Davies S, Gao F (2003) Discrepancies between clinical and postmortem diagnoses in critically ill patients: an observational study. Critical Care 7: R129-R132.
  10. Podbregar M, Voga G, Krivec B, Skale R, Pareznik R, et al. (2001) Should we confirm our clinical diagnostic certainty by autopsies? Intensive Care Med 27: 1750-1755.
  11. Neal RD, Tharmanathan P, France B, Din NU, Cotton S, et al. (2015) Is increased time to diagnosis and treatment in symptomatic cancer associated with poorer outcomes? Systematic review. Br J Cancer 112: S92-S107.
  12. Taccone FS, Artigas AA, Sprung CL, Moreno R, Sakr Y, et al. (2009) Characteristics and outcomes of cancer patients in European ICUs. Crit Care 13: R15.
  13. Dellinger RP, Mitchell ML, Rhodes A, Annane D, Gerlach H, et al. (2013) Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012. Intensive Care Med 39:165-228.
  14. Goldman L, Sayson R, Robbins S, Cohn LH, Bettmann M, et al. (1983) The value of the autopsy in three medical eras. N Engl J Med 308: 1000-1005.
  15. De Vlieger GY, Mahieu EM, Meersseman W (2010) Clinical review: What is the role for autopsy in the ICU? Crit Care 14: 221.
  16. Combes A, Mokhtari M, Couvelard A, Trouillet JL, Baudot J, et al. (2004) Clinical and autopsy diagnoses in the intensive care unit: a prospective study. Arch Intern Med 164: 389-392.
  17. Roberts IS, Benamore RE, Benbow EW, Lee SH, Harris JN, et al. (2012) Post-mortem imaging as an alternative to autopsy in the diagnosis of adult deaths: a validation study. Lancet 379: 136-142.
  18. Fröhlich S, Ryan O, Murphy N, McCauley N, Crotty T, et al. (2014) Are autopsy findings still relevant to the management of critically ill patients in the modern era? Crit Care Med 42: 336-343.
  19. Lemaire F (2003) Should the autopsy be resuscitated? Intensive Care Med 29: 518-521.
  20. Esteban A, Fernández-Segoviano P (1999) The autopsy as a tool to monitor diagnostic error. Intensive Care Med 25: 343-344.
  21. Sonderegger-Iseli K, Burger S, Muntwyler J, Salomon F (2000) Diagnostic errors in three medical eras: a necropsy study. Lancet 355: 2027-2031.
  22. Shojania KG, Burton EC, McDonald KM, Golman L (2003) Changes in rates of autopsy-detected diagnostic errors over time. A systematic review. JAMA 289: 2849-2856.
  23. Garrouste-Orgeas M, Timsit JF, Vesin A (2010) Selected Medical Errors in the Intensive Care Unit. Results of the IATROREF Study: Parts I and II. Am J RespirCrit Care Med 181:134-142.
  24. Xavier AC, Siqueira SA, Costa LJ, Mauad T, NascimentoSaldiva PH (2005) Missed diagnosis in hematological patients-an autopsy study. Virchows Arch 446: 225-231.
  25. Pastores SM, Dulu A, Voigt L, Raoof N, Alicea M, et al. (2007) Premortem clinical diagnoses and postmortem autopsy findings: discrepancies in critically ill cancer patients. Crit Care 11: R48.
  26. Moitra VK, Guerra C, Linde-Zwirble WT, Wunsch H (2016) Relationship Between ICU Length of Stay and Long-Term Mortality for Elderly ICU Survivors. Crit Care Med 44: 655-662.
  27. Thurnheer R, Hoess C, Doenecke C, Moll C, Muntwyler J, et al. (2009) Diagnostic performance in a primary referral hospital assessed by autopsy: evolution over a ten-year period. Eur J Intern Med 20:784-787.
  28. Grinberg LT, Ferraz da Silva LF, Galtarossa Xavier AC, NascimentoSaldiva PH, Mauad T (2008) Clinico-pathological discrepancies in the diagnoses of solid malignancies. Pathol Res Pract 204:867-873.
  29. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JW, et al. (2013) Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer 49: 1374-1403.
  30. Raoof S, Feigin D, Sung A, Raoof S, Irugulpati L, et al. (2012) Interpretation of plain chest roentgenogram. Chest 141: 545-558.
  31. Quekel LG, Kessels AG, Goei R, van Engelshoven JM (1999) Miss rate of lung cancer on the chest radiograph in clinical practice. Chest 115: 720-724.
  32. Wichmann D, Obbelode F, Vogel H, Hoepker WW, Nierhaus A, et al. (2012) Virtual autopsy as an alternative to traditional medical autopsy in the intensive care unit: a prospective cohort study. Ann Intern Med 156: 123-130.
  33. Schwarz MI, Albert RK (2004) "Imitators" of the ARDS: implications for diagnosis and treatment. Chest 125: 1530-1535.
  34. Gadkowski LB, Stout JE (2008) Cavitary pulmonary disease.ClinMicrobiol Rev 21: 305-333.
  35. Duffy MJ (2013) Tumor markers in clinical practice: a review focusing on common solid cancers. Med PrincPract 22: 4-11.
  36. Brenner DR, Scherer D, Muir K, Schildkraut J, Boffetta P, et al. (2014) A review of the application of inflammatory biomarkers in epidemiologic cancer research. Cancer Epidemiol Biomarkers Prev 23:1729-1751.
  37. Surbatovic M, Veljovic M, Jevdjic J, Popovic N, Djordjevic D, et al. (2013) Immunoinflammatory response in critically ill patients: severe sepsis and/or trauma. Mediators Inflamm 2013: 362793.
  38. Markanday A (2015) Acute Phase Reactants in Infections: Evidence-Based Review and a Guide for Clinicians. Open Forum Infect Dis 2: ofv098.
  39. Winters B, Custer J, Galvagno SM Jr, Colantuoni E, Kapoor SG, et al. (2012) Diagnostic errors in the intensive care unit: a systematic review of autopsy studies. BMJ QualSaf 21: 894-902.

Citation: Berlot G, Calderan C, Moro V, Bussani R, Zandonà L (2016) Missed Diagnosis of Cancer in Critically Ill Patients: A Single-Center Experience. J Clin Exp Pathol 6:299. Doi: 10.4172/2161-0681.1000299

Copyright: © 2016 Berlot G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.