alexa Protective Effect of Ginger (Zingiber officinale) on Alzheimer's disease Induced in Rats | OMICS International
E-ISSN: 2314-7326
P-ISSN: 2314-7334
Journal of Neuroinfectious Diseases
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business

Protective Effect of Ginger (Zingiber officinale) on Alzheimer's disease Induced in Rats

Visit for more related articles at Journal of Neuroinfectious Diseases

Abstract

The possible protective effect of Ginger on Alzheimer’s disease induced in rats was investigated. Ninety rats were used as follows: control group, AD protective group using AlCl3, 3rd, 4th, and 5th groups rats were received orally Rivastigmine, Ginger (108 and 216 mg/kg/day) respectively, for two weeks followed by combination of each treatment for another 4 weeks. 6th group is a therapeutic AD group, while 7th, 8th & 9th groups are AD rats treated with the same doses of Rivastigmine and Ginger for 12 weeks. At baseline and after each treatment, behavioral stress tests, Rotarod and T-Maze tests were done. At the end of all experiments rats' brains were dissected and prepared for determination of acetylcholine (Ach), acetycholinesterase (AchE) levels and histopathologic examination. This study indicated that AD-induced rats exhibited reduction in behavior, Rotarod and T-Maze tests, reduction in brain Ach and increase AchE levels. While rats treated with Rivastigmine and Ginger in protective and therapeutic groups exhibited significant improvement in behavior, Rotarod and T-Maze, significant increase in brain Ach and decrease AchE levels. These results were consistent with the histopathological findings and revealed Rivastagmine, and Ginger ameliorates neurodegeneration characters of Alzheimer’s diseases in rats.

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Article Usage

  • Total views: 13712
  • [From(publication date):
    June-2014 - Sep 22, 2020]
  • Breakdown by view type
  • HTML page views : 9766
  • PDF downloads : 3946
Top