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Risk Factors for Complications after Primary Repair of Achilles Tendon Ruptures
ISSN: 2329-910X
Clinical Research on Foot & Ankle
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  • Research Article   
  • Clin Res Foot Ankle, Vol 5(3): 244
  • DOI: 10.4172/2329-910X.1000244

Risk Factors for Complications after Primary Repair of Achilles Tendon Ruptures

Christian A Pean1,2, Anthony V Christiano1,2, William J Rubenstein1,2, Sanjit R Konda1,2 and Kenneth A Egol1,2*
1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, USA
2Jamaica Hospital Medical Center, Queens, NY, USA
*Corresponding Author: Kenneth A Egol, Professor and Vice-Chairman, Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, USA, Tel: 212-598-6137, Fax: 212-598-6015, Email: [email protected]

Received: 26-Jul-2017 / Accepted Date: 01-Aug-2017 / Published Date: 08-Aug-2017 DOI: 10.4172/2329-910X.1000244 /

Abstract

Background: Operative treatment of Achilles tendon ruptures is associated with lower rates of rereupture compared to nonoperative treatment. However, concerns regarding adverse events (AE) in the postoperative period such as wound complications and surgical site infection (SSI) persist. The purpose of this study was to identify patient characteristics associated with the occurrence of adverse events in Achilles tendon rupture (ATR) surgical repair cases.
Methods: Primary ATR repairs completed from 2005-2012 were identified in the ACS-NSQIP database. Univariate analyses were conducted to identify patient characteristics associated with 30 day postoperative complications. A high risk (HR) cohort group of patients who were either obese (Body Mass Index [BMI]>30), had a history of diabetes, or a history of smoking were compared to healthy controls. A multivariate logistic regression analysis of the overall cohort was done to assess for independent predictors of AEs.
Results: In total, 1,164 patients met inclusion criteria with 615 meeting criteria for the HR cohort (53%). Overall, 2% (n=23) of the group sustained an AE postoperatively and, the most common AE was superficial SSI (0.9%, n=10). Operative time was longer in HR group compared to other ATR cases in the study (57.95 ± 28.2 minutes vs. 63.16 ± 30.2 minutes, p=0.002). Multivariate analysis did not reveal any patient characteristics to be significantly associated with the occurrence of an adverse event or superficial SSI.
Conclusions: Rates of AEs in the 30 day postoperative period for surgically repaired ATR are very low. Obesity, diabetes and a history of smoking do not seem to predispose patients to AEs following repair of an ATR.

Keywords: Achilles tendon rupture; Diabetes; Outcome studies; Tendon disorders

Introduction

Achilles tendon rupture (ATR) is a fairly common injury that results in substantial morbidity with functional deficits persisting more than two years after the initial injury regardless of treatment [1]. The majority of Achilles tendon ruptures result from sports and exercise related activity [2,3].

These injuries occur more in males between the ages of 30 and 50, with an overall incidence of 6-37 per 100,000 people [4-6]. There has been an increased incidence in recent years among both men and women [7] with a peak in the spring that may be due to the increased frequency of adults playing recreational sports [8].

Broadly speaking, ATR can be treated either surgically or nonsurgically. Though surgical treatment has been trending downward, [7] there is currently no consensus among orthopaedic surgeons as to the optimal management of ATRs. A number of recent studies have compared outcomes and complications between surgical and nonsurgical treatment of ATR injuries. The results of these studies have shown lower re-rupture rates in surgically repaired ATR with a higher rate of other complications including infection and nerve injury [9-11].

Given these outcomes, concerns regarding adverse events in the postoperative period may influence the decision to pursue operative management in certain patients. It is important for surgeons to be able to identify those patients who are at a higher risk for experiencing adverse events and tailor treatment accordingly.

The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) is a multi-institutional outcomes database gaining increasing use in the field of orthopaedics to help analyze the various factors that contribute to adverse surgical outcomes [12,13].

It contains pre-operative, intra-operative, and 30 day follow up data that is prospectively collected using a standardized methodology resulting in a high quality and robust database. To our knowledge, no one has utilized the NSQIP database to analyze the overall incidence of adverse events and associated risk factors following Achilles tendon surgery.

The purpose of this study was to (1) identify patient characteristics associated with the occurrence of adverse events in Achilles tendon rupture and (2) compare outcomes in the perioperative period between patients with multiple risk factors and healthy patients.

Materials and Methods

The ACS-NSQIP database was queried for all primary ATR procedures defined as Current Procedural Terminology (CPT) codes 27650 (1085 cases) and 27652 (79 cases) performed in the years 2005-2012. Percutaneous ATR was not included in this analysis in order to have a more uniform cohort. Patients with missing demographic or outcomes information were excluded from analysis.

Adverse events were defined as the occurrence of any of the following: Death, coma>24 hrs, ventilator>48 hrs, unplanned intubation, stroke/cerebrovascular accident, deep venous thrombosis, pulmonary embolism, cardiac arrest, myocardial infarction, acute renal failure, sepsis, septic shock, return to operating room, wound dehiscence, deep SSI, organ/space infection, graft prosthesis failure, peripheral nerve injury, superficial surgical site infection (SSI), urinary tract infection, pneumonia, or progressive renal insufficiency. Superficial surgical site infection is defined in the NSQIP database as an open wound, cellulitis (erythema, tenderness and swelling), or wound infection was noted postoperatively at the surgical site.

A high risk (HR) cohort group was created by compiling patients who were either obese (Body Mass Index [BMI] >30), had a history of diabetes, or a history of smoking. These patients were compared for rates of adverse events to healthy control patients who had none of these risk factors using Pearson’s Chi square test for significant differences (p-value<0.05).

A multivariate logistic regression analysis of the overall cohort including obesity, history of smoking, diabetes, consumption of greater than two drinks of alcohol/day, age, gender, hypertension, and history of chronic obstructive pulmonary disease was completed to assess for independent predictors of adverse events. The model explained 3.4% of variance in adverse events and correctly classified 98.0% of cases. A subgroup analysis was completed to compare primary ATR repair with and without graft to ensure the patient groups could be combined and were comparable with regard to outcomes.

Results

In total, 1164 patients met inclusion criteria for the study. A subgroup analysis of the two CPT procedures included (27650 and 27652) revealed ATR repair patients with graft differed only in operative time compared to ATR repair patients without graft (58.34 ± 26.9 minutes, vs. 93.25 ± 40.41 minutes, p<0.001).

There was no statistically significant difference in the two procedure groups with regard to adverse events with only one patient in the ATR repair with graft group having a complication compared to 22 in the ATR repair without graft group. From the overall cohort, six hundred and fifteen met criteria for the HR cohort (53%).

Complete patient demographics are listed in Table 1. Overall, 2% (n=23) of the group sustained an adverse event during the 30 day postoperative period, the most common being superficial SSI (0.9%, n=10).

 Patient characteristics Overall High Risk
(N=1,164) (N=615)
Demographic
  Age, years 44.82 ± 13.32 48.19 ± 14.12
  Female sex (%) 25.60% 29.40%
Preoperative Comorbidities
  BMI, kg/m2 30.13 ± 6.46 33.79 ± 6.70
  Functional status (dependent) (%) 0.1 0.2
  Smoker within 1 year (%) 12.2 76.9
  Alcohol use (%) 0.9 1.1
  Steroid use (%) 1.1 1.3
  Weight loss (%) 0.1 0.2
  Diabetes (%) 5 10.4
  Hypertension (%) 22.5 34
  COPD (%) 0.8 1.1
  Open wound/wound infection (%) 1 1
Operative Variables  
Mean operative time, min 60.71±29.38 63.16 ± 30.19
BMI=Body Mass Index  

Table 1: Patient characteristics for overall Achilles tendon rupture repair cohort.

Frequency of specific complications in the overall cohort and the HR group are included in Table 2. There was no significant difference in the HR cohort versus controls in rates of adverse events (2% vs. 2%, p=0.981) or superficial SSI (0.9% vs. 0%, p=0.183). Operative time was significantly longer in HR group compared to healthy controls in the study (63.16 ± 30.2 minutes vs. 57.95 ± 28.2 minutes, p=0.002).

Outcome Count
(Overall N=1,164)
% of total
Any complication 23 2
Superficial wound infection 10 0.8
Deep wound infection 3 0.3
Wound dehiscence 3 0.3
Pneumonia 1 0.1
Deep-vein thrombosis 2 0.2
Reoperation 6 0.5
Values listed as percentages

Table 2: Thirty day postoperative complications in overall Achilles tendon rupture repair cohort

Logistic multivariate analysis did not reveal any patient characteristics included in the model to be significantly associated with the occurrence of an adverse event or superficial SSI (Table 3).

Outcome Odds ratio (95% CI) p value
Any adverse event
Obesity 0.57 (0.10-3.14) 0.52
History of Smoking 2.66 (0.71-10.03) 0.15
History of Diabetes 1.21 (0.51-14.26) 0.25
Age 1.01 (0.97-1.05) 0.81
Gender (Male) 1.05 (0.40-2.77) 0.93
History of Hypertension 0.39 (0.97-1.55) 0.18
History of COPD 6.94 (0.68-70.5) 0.1

Table 3: Multivariate Analysis of Risk Factors for Any Adverse Event.

Discussion

The patient population in this study was relatively young and healthy with an average age of 44.8 and few comorbidities. This is consistent with the epidemiology of ATRs documented in other literature [2,4,7]. The controversy regarding optimal management of ATR largely centers on weighing the risk of surgical complications against potentially longer recovery time and suboptimal functional results if patients are managed non operatively [14,15]. This study found a very low overall adverse event rate of 2% in the 30 day postoperative period for primary surgical ATR repair.

The HR cohort of patients had a statistically significantly higher operative time relative to healthy controls without risk factors. However, this difference of 6 minutes between the risk-stratified groups is likely not clinically significant. Patients undergoing ATR repair with graft had significantly higher operative time than those patients undergoing ATR repair without graft but did not differ in adverse event rates.

Though in this study there was no increased risk of adverse events across comparisons, increased operative time has been implicated as a risk factor for postoperative infection in numerous studies [16,17]. A comparison of operative and conservative management by Cukelji et al. found a lower rate of complications in patients undergoing percutaneous ATR repair and noted a lower operative time in these patients [14]. However, the sample size in their study was much smaller and specifically targeted athletes aged 25-40 years. Lower operative time did not correlate with lower incidence of complication in this study. However, it should be emphasized that the total recovery period for ATR extends far beyond the 30 day postoperative period.

Wound complications after ATR surgical repair have been documented as a concern that warrants consideration of non operative treatment for these injuries [18]. A retrospective study of 60 operatively managed ATR patients by Marican et al. found that 16.7% of patients suffered infectious complications [19].

In contrast to this study, we did not find an association between obesity and risk of superficial wound infections. Infection control protocols and antibiotic prophylaxis are not documented in the ACSNSQIP database, which makes it difficult to know if there were modifiable factors leading to lower infectious complications than rates previously reported in the literature.

As the population in the United States becomes more obese, concerns for increased risk of complications in patients with increased body habitus have risen [20]. In this study, patients with a higher risk profile did not have higher rates of complications relative to healthy controls. This suggests that for patients undergoing ATR surgical repair with risk factors explored in this study such as obesity, diabetes, and smoking, there isn’t a higher probability of surgical complications in the 30 day postoperative period compared to healthier patients. Surgical candidates for ATR repair with modifiable risk factors should nevertheless continue to be advised on the negative health effects of smoking, obesity, and diabetes. This is especially true given that complications typically associated with these conditions are likely to occur outside the 30 day postoperative period and are not captured in the NSQIP database. Age was not seen to impact 30 day complication rates, though previous studies have documented the potential benefits of ATR surgical repair vary based on patient age [21].

The ACS-NSQIP database provides the advantage of spanning numerous hospitals and minimizes the caveat of single surgeon bias. The patient population and rates of complications documented may be more representative of the overall U. S. population than other studies that rely on outcomes from a small cluster of institutions. Though the patient population in this study was comparable in size to others in the literature, the ACS-NSQIP database contained relatively few ATR compared to other conditions it has been used to investigate [22-24].

The small number of adverse events makes it difficult to draw broader conclusions based on statistical findings in this study as does the short follow up time. The logistic regression model only accounted for a small degree of the variation in adverse event occurrence. However, univariate analyses also did not find an association between patients in the HR cohort and adverse event occurrence.

There are also several limitations to this study inherent to the ACSNSQIP database. Patient outcomes are tracked up to thirty days after hospital admission and complications after this period are not documented [12]. The 30 day postoperative period is not indicative of long-term outcomes, though it is useful for minimizing patient readmissions and allows for analysis of imminent risks after surgery.

Given that re rupture may occur well outside the 30 day postoperative period and is a particular outcome of interest in ATR repair, it must be acknowledged that this limitation impedes the utility of this study’s results. Pain, range of motion, and outcomes commonly used in orthopaedic surgery are also not documented in the ACSNSQIP database. Furthermore, information on rehabilitation protocols, use of medical management such as thromboprophylaxis or antibiotic prohylaxis, and specified surgical technique would be beneficial for further analysis to better characterize predictors of a successful ATR repair [25]. This is particularly relevant given results from a recent meta-analysis concluding recommendations for surgical treatment be made based on availability of functional rehabilitation [26].

Conclusions

Repair of Achilles tendon ruptures has a very low rate of complications in the 30 day postoperative period even in patients with several complication rates. Patient characteristics were not seen to be predictive of adverse events in ATR operative cases in this study, though these results. Providers can use results from this study to further inform patient-physician discussions weighing the risks and benefits of operative vs. non-operative treatment for primary ATRs in the 30 day postoperative period.

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Citation: Pean CA, Christiano AV, Rubenstein WJ, Konda SR, Ego KA (2017) Risk Factors for Complications after Primary Repair of Achilles Tendon Ruptures. Clin Res Foot Ankle 5: 244. Doi: 10.4172/2329-910X.1000244

Copyright: © 2017 Pean CA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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