Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar


Unraveling the Conondrum-Small Bowel Pathology | OMICS International
ISSN: 2161-069X
Journal of Gastrointestinal & Digestive System

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business

Unraveling the Conondrum-Small Bowel Pathology

Brian Christopher* and Orlaith Kelly

Department of Gastroenterology, Connolly Hospital, Blanchardstown, Dublin, Ireland

Corresponding Author:
Brian Christopher
Specialist Registrar in Gastroenterology/Hepatology
Department of Gastroenterology, Connolly Hospital
Blanchardstown, Dublin, Ireland
Tel: 00353870677239

Received Date: June 22, 2016; Accepted Date: July 03, 2016; Published Date: July 10, 2016

Citation: Christopher B, Kelly O (2016) Unraveling the Conondrum-Small Bowel Pathology. J Gastrointest Dig Syst 6:453. doi: 10.4172/2161-069X.1000453

Copyright: © 2016 Christopher B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Gastrointestinal & Digestive System


A 45-year-old woman attended our care with chronic right iliac fossa pain, nausea and diarrhoea. She was admitted four months previously with respiratory symptoms and was treated for severe bilateral pneumonia and treated conservatively for small bowel obstruction.


Small bowel; Pneumonia

Case Report

A 45-year-old woman attended our care with chronic right iliac fossa pain, nausea and diarrhoea. She was admitted four months previously with respiratory symptoms and was treated for severe bilateral pneumonia and treated conservatively for small bowel obstruction. Her clinical condition was critical at that point of time, of which, she was managed in Intensive Care Unit and was intubated. She had a previous history of retained placenta post-delivery and unfortunately associated peritonitis and sepsis. She also had history of oophorectomy and salphingectomy in 1994. She did previously have a history of small bowel obstruction with zone of transition at right iliac fossa, which subsequently resolved with conservative treatment. A computed tomography (CT) of abdomen and pelvis performed showed zone of transition at distal ileum. Her inflammatory markers Creactive protein (CRP) was raised and she was covered with antibiotic, Piperacillin-Tazobactam 4.5 g tds intravenously. Her CRP was improving with albumin of 18 g/dl (30-40). After a multidisciplinary meeting discussion, the plan was for ileo-colonscopy when she was clinically better. Unfortunately, she developed worsening pain at her right iliac fossa and a trial of intravenous steroid was given. She did not respond to the steroids and her repeat imaging showed evidence of small bowel obstruction and perforation (Figure 1). Emergency laparotomy was performed and this showed dilated small bowel to the level of mid distal ileum. A stricture of small bowel was seen 40 cm from ileocaecal valve with evidence of tiny perforations at ileum. Approximately, 120 cm length of small bowel was resected (Figure 2).


Figure 1: CT abdomen/pelvis showed distended loops of mid small bowel (SB) with a transition from distended SB to normally distended SB and a transition from normally distended SB to collapsed bowel more inferiorly; Findings consistent with small bowel obstruction.


Figure 2: Small bowel with features of focal cobblestone, early stricture and patchy ulceration.

The histology was consistent with a diagnosis of Crohn's colitis, with fissuring ulcer and scarring of small bowel mucosa and transmural inflammation (Figure 3). An anti-Tumor Necrosis Factor (anti-TNF) blood screen was sent. She continued to have unremarkable postoperative recovery with nutritional support and engagement with physiotherapist. She was reviewed eight weeks later and was initiated on Infliximab Infusion. A colonoscopy was also arranged at six months post-op to assess the anastomosis site.


Figure 3: Small bowel mucosa with fissuring ulcer, scarring and transmural inflammation.


In reference to European Crohn’s and Colitis Organisation (ECCO) [1] statement 5E, extensive small bowel Crohn's disease should be treated with systemic corticosteroids and thiopurines or methotrexate. For patients who relapsed, anti-TNF therapy with or without thiopurine is an appropriate option if there is objective evidence of moderate or severely active disease [EL5, RG D]. Surgical options should also be considered and discussed at an early stage. Indications for urgent surgery include perforation, uncontrolled haemorrhage, toxic megacolon, bowel obstruction and abscess. Elective surgery is considered in patients with stricture, fistula, malignancy, malnutrition, poorly controlled disease despite optimised medical management and extra-intestinal manifestation [2].

Patients who have clinical features that suggest a poor prognosis currently appear to be the most suitable patients for early introduction of thiopurines, methotrexate and or anti-TNF therapy (ECCO Statement 5F1) [EL5 RG D]. The inflammatory burden is greater in extensive (>100 cm) than in localised small bowel disease involvement, often resulting in nutritional deficiencies. Early introduction of anti- TNF therapy should also be considered, especially in who have clinical indicators of poor prognosis. There are a few considered predictors of early post-operative recurrence after ileocolonic resection. These include patient related risk factor i.e. Smoking, disease related risk factors i.e. prior intestinal surgery [EL 1 and RG A], penetrating disease behaviour, perianal location and surgery related risk factors i.e. extensive small bowel resection (ECCO Statement 8A1) [EL2b, RG B]. In the recent ECCO guidelines 1, ileocolonoscopy is recommended within the first year after surgery where treatment decisions may be affected (Statement 8C).

Thiopurines are more effective than mesalazine or imidazole antibiotics alone in post-operative prophylaxis (Statement 8F). The use of internationally recognized Rutgeert’s score [3] in post-operative endoscopic assessment is beneficial (i0 and i1 imply endoscopic remission while i2- i4 imply recurrent endoscopic disease) (Table 1 and Figure 4). Absence of prophylactic treatment [EL1a, RG A] is associated with a higher risk of relapse. Prophylaxis is best started within two weeks of surgery, although an early start has not been proven superior to later treatment [EL5, RG D] (ECCO Statement 8H1). The duration of prophylaxis should be at least 2 years [EL1a, RG B]. In a randomised, Post-Operative Crohn’s Endoscopic Recurrence (POCER) trial [4], the study was conducted to evaluate a therapeutic strategy based on a risk stratification of patients, with further treatment step-up and adjustment if recurrence occurs on the basis of ileocolonoscopy.

Rutgeert’s Score Endoscopic description of findings
i0 no lesions
i1 ≤ 5 apthous ulcers
i2 > 5 apthous ulcers with  normal intervening mucosa, skip areas of larger lesions ileocolonic anastomosis
i3 diffuse aphthous ileitis with diffusely inflamed mucosa
i4 diffuse inflammation with larger ulcers, nodules and/or narrowing

Table 1: Rutgeert’s score in post-operative endoscopic assessment.


Figure 4: Rutgeert’s score in post-operative endoscopic assessment. Neoterminal ileum with Rutgeerts scores. (A) i1, (B) i2, (C) i3 and (D) i4.

The study involved 17 centers from Australia and New Zealand with 174 patients who had intestinal resection were enrolled. In the active care group, endoscopic recurrence was defined at 6-month colonoscopy using the Rutgeerts’ score; if the score was ≥ i2, the treatment was stepped up to thiopurine, adalimumab every 2 weeks combined with thiopurine or weekly adalimumab. In relation to our case above, our patient developed small bowel obstruction as a complication of Crohn’s colitis leading to emergency surgery. Among the initial presentation differential diagnosis include bowel adhesion with the previous surgical history and intra-abdominal abscess. Nutritional support is crucial at the time of and post-surgery.

Patients deficient in nutritional status should be supplemented, preferentially prior to surgery, to give a better surgical outcome. In our case, Infliximab was used as propylactic treatment post op to reduce risk of relapse. As per the guidelines, a colonscopy was arranged in six months for our patient to reassess the anastomosis site and exclude disease recurrence.


Small bowel obstruction is one of presentation complication features of Crohn’s colitis. Surgical treatment should not be viewed as last resort or treatment failure but as part of overall management plan. Post-operative prophylactic treatment is crucial to reduce recurrence risk. Ileocolonoscopy should be performed within 6-12 months after surgery to guide further management.


Post your comment

Share This Article

Article Usage

  • Total views: 10194
  • [From(publication date):
    August-2016 - Dec 01, 2023]
  • Breakdown by view type
  • HTML page views : 9524
  • PDF downloads : 670