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Journal of Clinical & Experimental Pathology
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  • Review Article   
  • J Clin Exp Pathol 2013, Vol 3(1): 137
  • DOI: 10.4172/2161-0681.1000137

A Brief Review of the Controversial Role of Iron in Colorectal Carcinogenesis

Margaret Cho#, Ogechukwu P Eze# and Ruliang Xu*
Department of Pathology, New York University Langone Medical Center, 550 First Avenue, New York, NY 10016, USA
#Contributed equally to this work
*Corresponding Author : Ruliang Xu, Department of Pathology, New York University Langone Medical Center, 550 First Avenue, New York, NY 10016, USA, Tel: 212 263 0728, Fax: 212 263 7916, Email: [email protected]

Received Date: Mar 29, 2013 / Accepted Date: Apr 29, 2013 / Published Date: May 01, 2013

Abstract

Colorectal Cancer (CRC) is the second and third most common cancer in females and males worldwide,
respectively. Major risk factors have been established for the development of CRC. These include susceptible
genetics, increased age (50 years), male gender, and race. The role of environmental factors in CRC pathogenesis
is evident but complex. Some environmental factors linked to CRC pathogenesis include diet, specifically red meat,
refined grains and starches, sugars, fat, alcohol, and chemicals. Implicated chemicals include arsenic, chromium,
nickel and iron. This article briefly reviews the evidence for the controversial role of iron in pathogenesis of CRC.
Proposed mechanisms for iron carcinogenesis involve various genetic and metabolic pathways, illustrating the
complex interplay of genetic and metabolic alterations in chemical carcinogenesis

Keywords: Iron; Colorectal cancer; Chemical carcinogenesisv

Citation: Cho M, Eze OP, Xu R (2013) A Brief Review of the Controversial Role of Iron in Colorectal Carcinogenesis. J Clin Exp Pathol 3:137. Doi: 10.4172/2161-0681.1000137

Copyright: © 2013 Cho M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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