A Brief Review of the Controversial Role of Iron in Colorectal Carcinogenesis
Received Date: Mar 29, 2013 / Accepted Date: Apr 29, 2013 / Published Date: May 01, 2013
Abstract
Colorectal Cancer (CRC) is the second and third most common cancer in females and males worldwide,
respectively. Major risk factors have been established for the development of CRC. These include susceptible
genetics, increased age (50 years), male gender, and race. The role of environmental factors in CRC pathogenesis
is evident but complex. Some environmental factors linked to CRC pathogenesis include diet, specifically red meat,
refined grains and starches, sugars, fat, alcohol, and chemicals. Implicated chemicals include arsenic, chromium,
nickel and iron. This article briefly reviews the evidence for the controversial role of iron in pathogenesis of CRC.
Proposed mechanisms for iron carcinogenesis involve various genetic and metabolic pathways, illustrating the
complex interplay of genetic and metabolic alterations in chemical carcinogenesis
Keywords: Iron; Colorectal cancer; Chemical carcinogenesisv
Citation: Cho M, Eze OP, Xu R (2013) A Brief Review of the Controversial Role of Iron in Colorectal Carcinogenesis. J Clin Exp Pathol 3:137. Doi: 10.4172/2161-0681.1000137
Copyright: © 2013 Cho M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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