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A Brief Review on Analysis of Cytokines' Role in Research | OMICS International| Abstract
ISSN: 2576-3881

Journal of Cytokine Biology
Open Access

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  • Review Article   
  • J Cytokine Biol 2023, Vol 8(3): 439
  • DOI: 10.4172/2576-3881.1000441

A Brief Review on Analysis of Cytokines' Role in Research

Qi Han Carrie*
Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasakiya University, Sakamo, Nagasakiya, Ethiopia
*Corresponding Author : Qi Han Carrie, Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasakiya University, Sakamo, Nagasakiya, Ethiopia, Email: qi.hancarrie@gmail.com

Received Date: May 05, 2023 / Published Date: May 31, 2023

Abstract

About 20 years ago, several organisations looking for genes with sequence homology to the cytokine family IL-1 found the IL-36 cytokines. One of these investigations, written up in 2001 by Debets and colleagues, showed that human keratinocytes expressed IL-1 and IL-1, now known as IL-36 and the IL-36R antagonist (IL-36Ra), respectively. This was especially true after stimulation with IL-1 and TNF. Three pro-inflammatory cytokines from the IL-36 family—IL-36, IL-36, and IL-36—as well as a receptor antagonist—IL-36Ra—bind to and signal through a heterodimeric receptor made up of IL-36R and the IL-1R accessory protein (IL-1RAcP). A result that directly connects dysregulated IL-36 pathway activation to inflammatory skin disorders is the development of generalised pustular psoriasis in people with inactivating mutations in the gene for IL-36Ra, a severe type of psoriasis. This review’s focus is on the cellular origins of IL-36 cytokines, the effects of IL-36 signalling on different cell types, and the relationship between IL-36 and a range of inflammatory skin conditions, such as different types of psoriasis, hidradenitis suppurativa, atopic dermatitis, and allergic contact dermatitis.

Citation: Carrie QH (2023) A Brief Review on Analysis of Cytokines’ Role in Research. J Cytokine Biol 8: 439. Doi: 10.4172/2576-3881.1000441

Copyright: © 2023 Carrie QH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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