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ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
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  • Research Article   
  • J Alzheimers Dis Parkinsonism 2018, Vol 8(2): 429
  • DOI: 10.4172/2161-0460.1000429

A Novel Dementia Scale for Alzheimer's Disease

Takashi Kikuchi*, Takahiro Mori, Kenji Wada-Isoe, Yumi Umeda-Kameyama, Tatsuo Kagimura, Shinsuke Kojima, Masahiro Akishita and Yu Nakamura
1Translational Research Informatics Center, Foundation for Biomedical Research and Innovation,, , 1-5-4 Minatojima-Minamimachi, Chuo-ku Kobe, Hyogo 650-0047, Japan
2Department of Neuropsychiatry, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan
3Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, 36-1, Nishi-cho, Yonago, Tottori 683-8504, Japan
4Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8665, Japan
*Corresponding Author : Takashi Kikuchi, Translational Research Informatics Center, Foundation for Biomedical Research and Innovation, 1-5-4 Minatojimaminamimachi, Chuo-ku Kobe, Hyogo 650-0047, Japan, Tel: +81-78-303-9107, Fax: +81-78-303-9094, Email: [email protected]

Received Date: Feb 13, 2018 / Accepted Date: Mar 02, 2018 / Published Date: Mar 09, 2018

Abstract

Objective: We established the diagnostic accuracy of the “ABC Dementia Scale” (ABC-DS) for Alzheimer’s disease (AD), which concurrently assesses activities of daily living (“A”), behavioral and psychological symptoms of dementia (“B”), and cognitive function (“C”), using a novel scoring approach called the three-dimensional distance (TDD).
Methods: The ABC-DS has 13 items with nine ordered categorical levels. Caregivers were interviewed using a semi-structured interview. The construct validity, concurrent validity, test-retest reliability, and responsiveness (score changes over 12 weeks) were assessed.
Results: We enrolled 63 participants with probable AD as well as 88, 106, and 55 patients with mild, moderate, and severe AD, respectively. The construct and concurrent validities of each domain score were determined. The TDD accurately discriminated the AD stages and detected score changes indicating disease progression over 12 weeks.
Conclusion: The ABC-DS is stable, accurately stages AD severity, and monitors disease progression. The TDD is a useful algorithm for detecting disease progression.

Keywords: Activities of daily living; Alzheimer’s disease; Cognitive function; Factor analysis; Item response theory; Receiver operating characteristic; Semi-structured interview; Three-dimensional distance; Multi-domain scale

Citation: Kikuchi T, Mori T, Wada-Isoe K, Umeda-Kameyama Y, Kagimura T, et al. (2018) A Novel Dementia Scale for Alzheimer’s Disease. J Alzheimers Dis Parkinsonism 8: 429. Doi: 10.4172/2161-0460.1000429

Copyright: © 2018 Kikuchi T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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