ISSN: 2155-6105

Journal of Addiction Research & Therapy
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  • Research Article   
  • J Addict Res Ther 488,

Analytical Method Development and Validation of Carbimazole by Using RP-HPLC on Bulk Drug and Marketed Formulation in Addiction Treatment

Kanchan R*, Poorvi SG and Phadtare DG
Assistant Professor, R.G. Sapkal Institute of Pharmacy, Anjaneri, Nashik, India
*Corresponding Author : Kanchan R, Assistant Professor, R.G. Sapkal Institute of Pharmacy, Anjaneri, Nashik, India, Email: Kanchan.pagr@sapkalknowledghub.org

Received Date: Aug 31, 2022 / Accepted Date: Sep 20, 2022 / Published Date: Sep 23, 2022

Abstract

The goal of the present study was to develop and validate of an analytical method for the evaluation of Clotrimazole in bulk form. UV-VIS spectroscopic technique was used for the estimation of Clotrimazole. Organic solvents and chemicals were used as trial diluents. The selection of the diluents was carried out on the basis of solubility and stability factors upon which drug was fully solubilised and stable for sufficient time. The drug was slightly soluble in water and acetonitrile, Soluble in Methanol and Alcohol. Clotrimazole showed absorption maxima (λ max) at 263 nm. The recovery studies were established the accuracy of the proposed method and the results were validated as per ICH guidelines. Linearity was obtained by concentration versus absorbance for Clotrimazole with correlation coefficient r꞊0.999. Robustness of the method was calculated as the % RSD for peak area was calculated which should be less than 2%.The LOD and LOQ were calculated as 0.000228(μg/mL), 0.00775 (μg/ mL) respectively. The result analysis was validated statistically and recovery studies confirmed the accuracy and precision of the proposed method. The developed method can effectively be applied for the quality control analysis and determination of Clotrimazole in tablet dosage form.

Citation: Kanchan R, Phadtare DG (2022) Analytical Method Development and Validation of Carbimazole by Using RP-HPLC on Bulk Drug and Marketed Formulation in Addiction Treatment. J Addict Res Ther 13: 488.

Copyright: © 2022 Kanchan R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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