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Antibiotic Prophylaxis in Colorectal Surgery: Evolving Trends | OMICS International| Abstract
ISSN: 2329-9053

Journal of Molecular Pharmaceutics & Organic Process Research
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  • Research Article   
  • J Mol Pharm Org Process Res 2013, Vol 1(3): 109
  • DOI: 10.4172/2329-9053.1000109

Antibiotic Prophylaxis in Colorectal Surgery: Evolving Trends

Peter A Ongom1* and Stephen C Kijjambu2
1Colorectal Unit, Department of Surgery, School of Medicine, Makerere University College of Health Sciences, Makerere University, Kampala, Uganda
2Department of Surgery, School of Medicine, Makerere University College of Health Sciences, Makerere University, Kampala, Uganda
*Corresponding Author : Peter A Ongom, Colorectal Unit, Department of Surgery, School of Medicine, Makerere University College of Health Sciences, Makerere University, P O Box 7072, Kampala, Uganda, Tel: 256-772-454- 936/256-701-629- 160, Email:

Received Date: Oct 29, 2013 / Accepted Date: Dec 18, 2017 / Published Date: Dec 30, 2013


Introduction: Surgical antibiotic prophylaxis has become standard practice for patients undergoing colorectal surgery. This clinical practice has changed greatly over the last three decades, and it is currently accepted worldwide. It is phenomenal in minimizing postoperative wound infection in elective surgery. Clinical practice guidelines have been developed to herald this. However, the practice is yet to be established in some regions, particularly lowincome countries. A review of the evolution of the practice is necessary.

Clinical Overview: Being a clean-contaminated procedure, colorectal surgery is a typical indication for antibiotic prophylaxis. The antibiotic for use is chosen on the basis of – its activity against endogenous flora likely to be encountered, its toxicity, and its cost, in that order. Controversy persists concerning the route of administration (oral, intravenous, or both), the number of administrations, and the duration of prophylaxis. Potent antibiotics used for serious infections are essentially not used for this purpose. A maximum dose is given preoperatively so that effective tissue concentration is present at and after the time of incision. In the absence of infection, the antibiotic is discontinued after the operative day.

Systematic improvements in the timing of initial administration, the appropriate choice of antibiotic agents, and shorter durations of administration have added value to the practice, with reductions in postoperative surgical infections, especially surgical site infections, for colorectal (clean-contaminated) procedures. The prevention of surgical site infections is an objective contained in the WHO Guidelines for Safe Surgery. They are a potentially morbid and costly complication following major colorectal surgery.

Conclusions: The practice of prophylaxis in surgery continues to improve. In recent years, growing attention is being placed on the accurate identification and monitoring of surgical complications and their costs. Advancements in antibiotic development and usage will translate into better prophylactic measures, which alongside other measures for control of surgical infections will give a better outcome for colorectal surgery.

Keywords: Antibiotics; β,-lactamase; β-lactam Antibiotics; Colorectal Surgery; Drug Dosing and Re-dosing; Guidelines; Mechanical Bowel Preparation; Pathogens; Surgical Prophylaxis; Surgical Site Infections; Recommendations

Citation: Ongom PA, Kijjambu SC (2013) Antibiotic Prophylaxis in Colorectal Surgery: Evolving Trends. J Mol Pharm Org Process Res 1: 109 Doi: 10.4172/2329-9053.1000109

Copyright: ©2013 Ongom PA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited