alexa Basic Science and Clinical Application of Platelet-Rich

Cosmetology & Oro Facial Surgery
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Review Article

Basic Science and Clinical Application of Platelet-Rich Plasma in Fat Grafting: A Concise Review

Eric Ruff, Donald C Ewing, Raghavendra L Girijala and Takashi Hirase*

Texas A&M University Health Science Center College of Medicine, 8447 Texas 47, Bryan, Texas, United States

*Corresponding Author:
Takashi Hirase
Texas A&M University Health Science Center College of Medicine
8447 Texas 47, Bryan, Texas, 77807, United States
Tel: +1 310 869-5034
E-mail: [email protected]

Received date: April 14, 2017; Accepted date: May 28, 2017; Published date: June 01, 2017

Citation: Ruff E, Ewing DC, Girijala RL, Hirase T (2017) Basic Science and Clinical Application of Platelet-Rich Plasma an Fat Grafting: A Concise Review. Cosmetol & Oro Facial Surg 3:116.

Copyright: © 2017 Ruff E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Platelet-rich plasma (PRP) is an autologous preparation of concentrated platelets containing over 30 bioactive molecules including PDGF, TGF-β, VEGF, and EGF. The first use of PRP in augmenting regenerative medicine was described in 1998, when autologous PRP was used to aid cancellous bone graft maturation in patients with mandibular defects. Since that time, PRP has been implemented in a variety of procedures, ranging from joint replacements and hernia repair to pituitary tumor removal and radical neck dissections. Given the advancements in technology over the past 2 decades, this paper will summarize the cellular mechanisms underlying PRP, as well as discuss its clinical utility in autologous fat grafting and future roles in cosmetic plastic surgery.


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