alexa BlaOXA-23 and blaNDM-1 Genotypes Co-existence in Clinical Isolates of <em>Acinetobacter baumannii</em> Producing the Carbapenemase from Mayotte Hospital Center| Abstract
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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  • Research Article   
  • J Infect Dis Ther,

BlaOXA-23 and blaNDM-1 Genotypes Co-existence in Clinical Isolates of Acinetobacter baumannii Producing the Carbapenemase from Mayotte Hospital Center

Abdoulahy Diallo1, Issifou Yaya2*, Maxime Raz3, Celine Michaud1, Maxime Jean1, Mohamadou Niang1 and Sarah Perma1
1Service de Médecine Polyvalente, Centre Hospitalier de Mayotte, Mamoudzou, France
2IRD, Inserm, Univ Montpellier, TransVIHMI, Montpellier, France
3Laboratoire de Biologie Medicale, Centre Hospitalier de Mayotte, Mamoudzou, France
*Corresponding Author : Issifou Yaya, IRD, Inserm, Univ Montpellier, TransVIHMI, Montpellier, France, Email: [email protected]

Received Date: May 25, 2020 / Accepted Date: Jun 09, 2020 / Published Date: Jun 16, 2020

Abstract

Background: Multidrug-resistant Acinetobacter baumannii is an increasing problem worldwide. The objective of this study was to describe the outbreak of Acinetobacter baumannii producing carbapenemases at the Mayotte Hospital Center.
Methods:
This is a descriptive study using routine data collected prospectively in patients' medical records. From the different services (Emergency, Intensive Care, Surgery, pediatrics, Medicine) between 2016 and 2019. The A. baumannii strains were collected from biological samples and rectal swabs. The isolates were identified using the API®20NE and VITEK®2. Each strain was confirmed by molecular typing and molecular basis by PCR.
Results:
80 patients were included in this analysis. The median age of the patients was 48 years (interquartile range (IQR): 33.3 – 57 years). They were mostly male (63.7%). Half of the patients were Comorian (73.8%). More than half of the cases were collected in ICU (41.2%). The isolation period lay between 1 and 120 days with median duration of 11.5 days (4.3 – 23.5 days. A blaNDM-1 and blaOXA-23 genotypes coexistence was observed in 70% of the patients. Eleven deaths were observed.
Conclusions: This study showed that the epidemic as changed with the detection of blaNDM-1 and blaOXA-23 genotypes coexistence. In addition, efforts to control the spread of A. baumannii producing carbapenemase and surveillance measures are urgently needed to Mayotte.

Keywords: Acinetobacter baumannii; blaNDM-1 and blaOXA-23 genotypes coexistence; Mayotte

Citation: Diallo A, Yaya I, Raz M, Michaud C, Jean M, et al (2020) BlaOXA-23 and blaNDM-1 Genotypes Co-existence in Clinical Isolates of Acinetobacter baumannii Producing the Carbapenemase from Mayotte Hospital Center. J Infect Dis Ther 8: 429.

Copyright: © 2020 Diallo A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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