Abstract

The integration of palliative care (PC) into neonatal intensive care units (NICUs) for infants with complex congenital brain defects represents a critical advancement in neonatal medicine. These conditions, such as holoprosencephaly, lissencephaly, and severe hydrocephalus, often carry poor prognoses, necessitating a balance between life-sustaining interventions and comfort-focused care. This article examines how PC can bridge the gap between aggressive treatment and family-centered support in the NICU. By reviewing current integration strategies, outcomes, and challenges, it highlights the potential for improved quality of life for neonates and their families. The findings underscore the need for interdisciplinary collaboration, early PC involvement, and tailored communication to optimize care for this vulnerable population