alexa Clinical Differences between Methicillin-Resistant and -Susceptible <em>Staphylococcus aureus</em> Bacteremia in Adult Patients at a Tertiary Hospital in Japan| Abstract
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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  • Research Article   
  • J Infect Dis Ther,

Clinical Differences between Methicillin-Resistant and -Susceptible Staphylococcus aureus Bacteremia in Adult Patients at a Tertiary Hospital in Japan

Yuji Watanabe1,2, Kazuki Takano1,2, Maya Hariu1,2, Yasuhiro Kamioka1,3, Daishi Shimada1, Haruka Imai1, Katsuhiro Fuse3 and Masafumi Seki1*
1Division of Infectious Diseases and Infection Control, Tohoku Medical and Pharmaceutical University Hospital, Sendai City, Japan
2Laboratory for Clinical Microbiology, Tohoku Medical and Pharmaceutical University Hospital, Sendai City, Japan
3Department of Pharmacy, Tohoku Medical and Pharmaceutical University Hospital, Sendai City, Miyagi, Japan
*Corresponding Author : Masafumi Seki, Division of Infectious Diseases and Infection Control, Tohoku Medical and Pharmaceutical University Hospital, Sendai City, Japan, Email: [email protected]

Received Date: May 22, 2020 / Accepted Date: Jun 11, 2020 / Published Date: Jun 18, 2020

Abstract

To determine clinical differences in features of methicillin-susceptible and resistant Staphylococcus aureus (MSSA and MRSA, respectively) bacteremia, 15 adult patients with MRSA bacteremia were compared with 30 adult patients with MSSA bacteremia who were hospitalized during 2015 – 2018.

Compared with MSSA bacteremia patients, MRSA bacteremia patients had a higher age (mean age, 82.0 years and 72.5 years, respectively) and were more likely to have diabetes mellitus significantly (p=0.04). Liver and kidney functions were also significantly decreased in MRSA bacteremia patients compared with MSSA bacteremia patients (p=0.037, p=0.001 and p=0,015, respectively). Moreover, MRSA bacteremia patients showed a much higher mortality rate than MSSA bacteremia patients (60% and 20%, respectively; odds ratio: 2.66, 95% CI; 1.806-4.288, p=0.007).

These data suggest that MRSA bacteremia is more lethal than MSSA bacteremia in adults. Thus, caution should be taken when Staphylococcus aureus is isolated from the blood of patients who are elderly, diabetic, or have liver and kidney dysfunction because MRSA can be more possible pathogens rather than MSSA.

Keywords: Age; Methicillin-resistant Staphylococcus aureus (MRSA); Methicillin-susceptible Staphylococcus aureus (MSSA); Liver dysfunction; Kidney dysfunction

Citation: Watanabe Y, Takano K, Maya H, Kamioka Y, Shimada D, et al. (2020) Clinical Differences between Methicillin-Resistant and - Susceptible Staphylococcus aureus Bacteremia in Adult Patients at a Tertiary Hospital in Japan. J Infect Dis Ther 8: 427.

Copyright: © 2020 Watanabe Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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