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Clinical Findings Showing that Non-Convulsive Electric Shock Administration for Patients Receiving Clozapine Therapy for Schizophrenia May Contribute to Stability of Granulocyte Number, the Most Critical Drug Side-Effect| Abstract

Clinical Neuropsychology: Open Access
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  • Case Study   
  • J Neuropsychopharmacol Mental Health 2017, Vol 2(1): 115

Clinical Findings Showing that Non-Convulsive Electric Shock Administration for Patients Receiving Clozapine Therapy for Schizophrenia May Contribute to Stability of Granulocyte Number, the Most Critical Drug Side-Effect

Kotaro Sugita, Yasuhiro Mori, Kousuke Kanemoto and Sotaro Sugita*
Department of Neuropsychiatry, Aichi Medical University, Nagakute- shi, Japan
*Corresponding Author : Sotaro Sugita, Department of Neuropsychiatry, Aichi Medical University, P.O. 480-1195, Yazako Karimata, 1–1, Nagakute-shi, Aichi Prefecture, Japan, Tel: + 81561623311, Email: [email protected]

Received Date: Jan 09, 2017 / Accepted Date: Feb 11, 2017 / Published Date: Feb 20, 2017

Abstract

Two treatment-resistant schizophrenic patients were administered clozapine, but showed a decrease in granulocytes. As an alternative treatment, we administered non-convulsive Electric Shock Therapy (ECT) (modified- ECT: m-ECT) to both and the number of granulocytes increased to a level considered safe for clozapine ingestion. Then, under continuation of m-ECT, we gradually increased the dose of the drug. After 10-14 m-ECT sessions in both patients, the number of granulocytes became stable at approximately 5000/mm3 and m-ECT was completed. Our findings show the possibility of treatment for therapy-resistant patients who are unable to receive clozapine because of reduced granulocyte number.

Keywords: Clozapine therapy; Electric shock; Schizophrenia; Granulocytes

Citation: Sugita K, Mori Y, Kanemoto K, Sugita S (2017) Clinical Findings Showing That Non-Convulsive Electric Shock Administration for Patients Receiving Clozapine Therapy for Schizophrenia May Contribute to Stability of Granulocyte Number, the Most Critical Drug Side-Effect. J Neuropsychopharmacol Mental Health 2: 115.

Copyright: © 2017 Sugita K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any Smedium, provided the original author and source are credited.

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