alexa Clinicopathological Assessment of Patients with Locally Advanced Breast Cancer with 10 or More Lymph Node Metastases
ISSN: 2572-4118

Breast Cancer: Current Research
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Research Article

Clinicopathological Assessment of Patients with Locally Advanced Breast Cancer with 10 or More Lymph Node Metastases

Satoki Kinoshita1*, Naoko Fukushima1, Ryo Miyake1, Takayuki Ishigaki1, Akio Hirano1, Tadashi Akiba1, Rei Mimoto2, Ken Uchida2, Hiroshi Takeyama2 and Toshiaki Morikawa2

1Department ofSurgery, Jikei University Kashiwa Hospital, Japan

2Department of Breast and Endocrine Surgery, Jikei University School of Medicine, Japan

*Corresponding Author:
Satoki Kinoshita
Department of Surgery
Jikei University Kashiwa Hospital
Tel: 81-4-7164-1111
E-mail:satokino0918@nifty.com

Received date: May 01, 2016; Accepted date: May 14, 2016; Published date: May 30, 2016

Citation: Kinoshita S, Fukushima N, Miyake R, Ishigaki T, Hirano A, et al. (2016) Clinicopathological Assessment of Patients with Locally Advanced Breast Cancer with 10 or More Lymph Node Metastases. Breast Can Curr Res 1:107. doi:10.4172/2572-4118.1000107

Copyright: © 2016 Kinoshita S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

 

Abstract

Background and Objective: Prognosis is generally very poor in patients with breast cancer with 10 or more axillary node metastases, but long-term recurrence-free survival is observed. We assess the clinicopathological features of these patients with and without recurrent disease and review the literature. Patients and Methods: We retrospectively examined the background, clinicopathological features, and prognoses of 29 patients who underwent surgery at our hospital for primary breast cancer with 10 or more axillary lymph node metastases between April 2003 and March 2015 and compared findings between those with and without disease recurrence. Metastases were identified based on hematoxylin and eosin staining. Results: The mean number of lymph node metastases was 19 and of dissected lymph nodes, 26. The cumulative disease-free survival plateaued at 59% 3 years after treatment, and the cumulative overall survival rate was 68.4% at 5 years and plateaued at 61% at 6 years. The mean disease-free survival was significantly shorter in those whose disease recurred (13.6 months) than those without recurrence (62.2 months). The expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) differed significantly between the 2 groups. Conclusion: Prognosis is generally very poor in patients with breast cancer with 10 or more axillary node metastases if tumors recur within 3 years. Furthermore, findings of all five patients with recurrent disease demonstrating a triple-negative subtype and all 14 patients without recurrence demonstrating luminal A intrinsic subtype suggest the use of these subtypes as prognostic factors.

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