ISSN: 2572-4118
Breast Cancer: Current Research
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Metastatic Breast Cancer
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Metastatic Breast Cancer
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Metastatic Breast Cancer
Metastatic breast cancer (likewise called stage IV or propelled bosom tumor) is bosom malignancy that has spread past the breast to different organs in the body (regularly the bones, lungs, liver or cerebrum).
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Breast Cancer: Current Research, Cancer Surgery, Clinical & Experimental Oncology, Clinical Oncology and Practice, Women's Health Care, Breast cancer research, Cancer and metastasis reviews, Cancer growth and metastasis, Breast cancer: basic and clinical research
Metastatic Breast Cancer
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Classically, the 3ââ¬â¢untranslated region (3ââ¬â¢UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3ââ¬â¢UTR alone, without all other elements in mRNA such as 5ââ¬â¢UTR and coding region. The importance of independent 3ââ¬â¢UTR RNA (referred as I3ââ¬â¢UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3ââ¬â¢UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3ââ¬â¢UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3ââ¬â¢UTR were important for its tumor suppression activity. Then, the C/EBP 3ââ¬â¢UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3ââ¬â¢UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3ââ¬â¢UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990ââ¬â¢s to 2000ââ¬â¢s, world scientists found several 3ââ¬â¢UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3ââ¬â¢UTR regions, although the existence of their transcribed products as independent 3ââ¬â¢UTR RNAs is still to be confirmed. Our studies indicate that the independent 3ââ¬â¢UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
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Resveratrol modulates expression of ABC transporters in non-small lung cancer cells: Molecular docking and gene expression studies
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Does a salutogenic attitude increase life quality after prostate cancer treatment?
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Na,K-ATPase isoform-selective cardiac glycosides- a potential anti-cancer drug ?
PPT Version | PDF Version - Tamar Geiger
Genome-Scale Proteomic Profiling of Breast Cancer Progression
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Mark cancer cells for CTL attack through coating with viral antigenic peptides CTLs kill tumor with viral peptides
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Localized regulated expression of IL-12 as a gene therapy approach to cancer immunotherapy
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Geriatric Oncology: Caring for the older patient with cancer
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Using DNA copy number aberrations in naturally occurring canine cancers to identify candidate drivers of carcinogenesis
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Effects of SulfonatedZinc Phthalocyanine and Low Intensity Laser Irradiation in Inducing Photodynamic Damagein Breast Cancer Cells
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Nanocolloidsfor Cancer
PPT Version | PDF Version - Yajun Yi
Meta-analysis of transcriptional profiles in cancer for prognosis prediction and metastatic gene identification
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Double Targeting as an Effective Anti-Cancer Strategy
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Gene expression profiling for targeted cancer treatment
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Construction of cancer pathways for personalized medicine
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Bacteria-mediated expression of cargo drugs and reporter gene for cancer-specific theranostics
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A proteomic-bioinformatic integrated approach for studying the effect of a peptide drug candidate on ovarian Cancer
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Translating multidimensional cancer omics data into biological insights
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Stimuli-sensitive combination nanopreparations of siRNA and chemotherapeutic drugs to treat multidrug resistant cancer
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Development of Sphingosine Kinase Inhibitors for Cancer Therapy
PPT Version | PDF Version - Charles F. L. Mbakaya
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