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Hindi Combating Parkinson's Disease with Plant-Based Polyphenols: Tackling Oxidative Stress and Neuroinflammation
*Corresponding Author:Received Date: Mar 03, 2025 / Published Date: Mar 31, 2025
Copyright: © 0 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Parkinson’s disease (PD) is a chronic neurodegenerative disorder that affects millions of individuals worldwide,
leading to motor and cognitive impairments. Oxidative stress and neuroinflammation are central to the pathophysiology
of PD, exacerbating neuronal damage and accelerating disease progression. Recent research suggests that plantbased
polyphenols, natural compounds abundant in fruits, vegetables, and other plant sources, offer potential
therapeutic benefits in mitigating these underlying mechanisms. These polyphenols, including flavonoids, resveratrol,
and curcumin, exhibit powerful antioxidant and anti-inflammatory properties that can reduce oxidative damage,
suppress neuroinflammation, and promote neuroprotection. This review examines the molecular mechanisms by which
polyphenols exert their effects on oxidative stress and neuroinflammation in the context of PD, highlighting their promise
as complementary interventions for managing and potentially modifying the course of Parkinson’s disease.
