Confocal Laser Endomicroscopy: The Potential Role of In Vivo Characterization of Neoplasia in the Gastrointestinal TractYutaka Tomizawa and Vani JA Konda*
Center of Endoscopic Research and Therapeutics (CERT), Section of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Chicago Medicine, 5841 S Maryland, Chicago, USA
- *Corresponding Author:
- Vani JA Konda
Director of Endoscopic Research and Educational Programs
for the Center of Endoscopic Research and Therapeutics (CERT)
Section of Gastroenterology, Hepatology and Nutrition
Department of Medicine, The University of Chicago Medicine 5841 S Maryland
E-mail: [email protected]
Received Date: March 31, 2014; Accepted Date: July 22, 2014; Published Date:July 24, 2014
Citation: Tomizawa Y, Konda VJA (2014) Confocal Laser Endomicroscopy – The Potential Role of In Vivo Characterization of Neoplasia in the Gastrointestinal Tract. J Clin Exp Pathol 4:181. doi: 10.4172/2161-0681.1000181
Copyright: © 2014 Tomizawa Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Confocal laser endomicroscopy (CLE) is a novel microscope which enables real-time imaging with detailed mucosal and sub mucosal architectures throughout the gastrointestinal tract. New optical technology using the principle of light reflection, scattering and refocusing dramatically increases image resolution thus has the potential of real time optical biopsy. Two types of CLE system are commercially available; endoscope-based type (eCLE) which integrated CLE in the tip of scope and probe-based type (pCLE) which uses a probe through the accessory channel of a traditional endoscope. Clinical data applying CLE for the detection of neoplastic lesions in the gastrointestinal tract have been increasingly reported including esophagus, stomach and colon. The probe based system has a probe that can be used in the bile ducts to evaluate biliary strictures. More recently, a needle based CLE which passes through a fine-needle aspiration needle has been introduced into pancreatic cystic lesions. CLE has demonstrated promising in vivo data in various clinical arenas. Further validation regarding reproducible image classification, inter and intra observer variability, learning curve, and cost effectiveness remain to be demonstrated.