ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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  • Review Article   
  • J Infect Dis Ther,
  • DOI: 10.4172/2332-0877.1000417

Coronaviruses and the Associated Potential Therapeutics for the Viral Infections

Shilei Wang1, Yichi Zhang2, Shuo Liu3, Hongmei Peng4, Vienna Mackey1 and Lichun Sun1,2,3*
1Shenzhen Academy of Peptide Targeting Technology at Pingshan and Shenzhen Tyercan Bio-Pharm Co., Ltd, Guangdong, China
2Department of Medicine, School of Medicine, Tulane University Health Sciences Center, New Orleans, USA
3Sino-US Innovative Bio-Medical Center and Hunan Beautide Pharmaceuticals, Hunan, China
4Scientific Research and Education Department, The First Peoples Hospital of Changde City, Changde, China
*Corresponding Author : Lichun Sun, Department of Medicine, School of Medicine, Tulane University Health Sciences Center, New Orleans, USA, Tel: +1-504-988-1179, Email: lsun@tulane.edu

Received Date: Feb 21, 2020 / Accepted Date: Mar 02, 2020 / Published Date: Mar 09, 2020

Abstract

Coronaviruses (CoVs), named after the crown-like spikes on their surfaces, belong to the RNA virus family Coronaviridae. Coronaviruses are enveloped RNA viruses with a linear positive-sense single–stranded genome consisting of the open reading frames (ORFs), the 5’- methylated cap, and the 3’- poly (A) tail. The open reading frames encode structural proteins and nonstructural proteins that may be drug-targetable. Antiviral medications seek to target these key proteins via different mechanisms. There have been seven coronaviruses discovered that are capable of infecting human beings, three of which including MERS-CoV, SARS-CoV and SARS-CoV-2, originated in wild animals and evolved to develop rapid human-to-human transmission, resulting in severe respiratory diseases among other pathologies, even deaths. Particularly, the outbreak of the novel Wuhan coronavirus SARS-CoV-2 has now rapidly spread across China and into many other countries. Sadly, there is no any effective vaccine or specific drug available. Many patients infected with SARS-CoV-2 have succumbed. Thus, there is a burning need for the anti-coronavirus drug development. The antiviral prodrug, Remdesivir, developed by the company Gilead, is currently under clinical investigation in China.

Keywords: Coronavirus; Structural proteins; Non-structural proteins; Infection; Drug; Vaccine

Citation: Wang S, Zhang Y, Liu S, Peng H, Mackey V, et al. (2020) Coronaviruses and the Associated Potential Therapeutics for the ViralInfections. J Infect Dis Ther 8: 417. Doi: 10.4172/2332-0877.1000417

Copyright: © 2020 Wang S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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