Cytidine 5’-triphosphate Synthetase: A Pyrimidine Biosynthetic Enzyme Critical to Cellular Synthesis and Cancer Chemotherapy
Received Date: Nov 27, 2018 / Accepted Date: Nov 27, 2018 / Published Date: Dec 04, 2018
Abstract
The pyrimidine biosynthetic enzyme Cytidine 5’-triphosphate (CTP) synthetase has an important role in the biosynthesis of RNA, DNA and phospholipids. The synthetase has been found to be highly regulated at the level of enzyme activity and enzyme synthesis in both prokaryotes and eukaryotes including humans. The enzyme has been the target of inhibition by various drugs since cellular proliferation requires CTP synthesis. The design of new drugs targetting CTP synthetase activity in humans could prove important to cancer chemotherapies since it may allow new cancer treatment procedures to be developed.
Keywords: Cytidine 5’-triphosphate synthetase; Pyrimidine biosynthesis; Phospholipid synthesis; Nucleic acid synthesis; Cancer chemotherapy
Citation: West TP (2018) Cytidine 5’-triphosphate Synthetase: A Pyrimidine Biosynthetic Enzyme Critical to Cellular Synthesis and Cancer Chemotherapy. Biochem Physiol 7: e160. Doi: 10.4172/2168-9652.1000e160
Copyright: © 2018 West TP. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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