Cytokine-Dependent Expression Regulation of ALOX15
Received Date: Mar 31, 2016 / Accepted Date: May 26, 2016 / Published Date: May 31, 2016
Lipoxygenases (LOX) are lipid-peroxidizing enzymes that play a role in cell differentiation, but have also been implicated in the pathogenesis of inflammatory, hyperproliferative and neurological disorders. They are widely distributed in plants and mammals but also occur sporadically in lower organisms. The human genome involves six functional LOX genes and a corrupted pseudogene. 20 years ago it was reported that expression of ALOX15 was specifically induced in human peripheral monocytes by the classical Th2 cytokine interleukin 4 and later expression array profiles indicated that this enzyme is the most strongly upregulated gene product in human monocytes. Although the molecular basis for this IL4-dependent expression regulation has extensively been studied during the past 20 years, there are still a number of unsolved questions. This review is aimed at summarizing the current knowledge on the cytokine-dependent expression regulation of ALOX15 with particular focus on the Th2 cytokines interleukin-4 and interleukin-13 in various cells and tissues and at critically evaluating the potential biological implication of this effect.
Keywords: Eicosanoids; Lipoxygenase; Leukotrienes; Inflammation; Energy metabolism
Citation: Kuhn H, Gehring T, Schröter A, Heydeck D (2016) Cytokine-Dependent Expression Regulation of ALOX15. J Cytokine Biol 1: 106. Doi: 10.4172/2576-3881.1000106
Copyright: © 2016 Kuhn H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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