Abstract

Background: It is chronic neurodegenerative disease which usually starts slowly and worsens over a period of time. Microscopy of brain in people affected with Alzheimer Disease (AD) show amyloid plaques and neurofibrillary tangles.

Materials and methods: We conducted this research paper by observing the different types of reviews, as well as conducting and evaluating literature review papers.

Results: The treatment currently available to treat Alzheimer disease only addresses symptoms rather than the underlying cause, but research that focuses on the amyloid hypothesis and improves understanding of this proteins role in the disease is hoped to lead to the development of new treatments that may be able to delay or stop disease progression.

Conclusion: Microscopic examination of the brains of Alzheimer's Disease (AD) patients reveals amyloid plaques and neurofibrillary tangles. Amyloid plaques are accumulations of misfolded proteins that form in the spaces between neurons. This research that focuses on the amyloid hypothesis and improves understanding of this protein’s role in the disease is hoped to lead to the development of new treatments that may be able to delay or stop disease progression.

Keywords: Alzheimer; Etiology; Stage; Complication; Diagnosis; Amyloid plaque; Treatment