Determination of the Cell Orientation Pathway and Receptor Complex Signals
Received Date: Apr 10, 2023 / Accepted Date: May 03, 2023 / Published Date: May 08, 2023
Abstract
Vertebrate proteins activate several distinct pathways. Intrinsic differences among ligands and Frizzled receptors, and the availability of pathway-specific co receptors. A secreted glycoprotein, Cthrc1, is involved in selective activation of the planar cell polarity pathway by proteins. Cell-surface-anchored Cthrc1 bound to proteins, Frizzled proteins, and Ror2 and enhanced the interaction of proteins and Frizzled /Ror2 by forming the Cthrc1 - Frizzled /Ror2 complex. These results suggest that Cthrc1 is a Frizzled cofactor protein that selectively activates the Frizzled /PCP pathway by stabilizing ligand-receptor interaction.
Citation: Pitters H (2023) Determination of the Cell Orientation Pathway and Receptor Complex Signals. J Biochem Cell Biol, 6: 186.
Copyright: © 2023 Pitters H. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Share This Article
Recommended Journals
Open Access Journals
Article Usage
- Total views: 282
- [From(publication date): 0-2023 - May 30, 2024]
- Breakdown by view type
- HTML page views: 232
- PDF downloads: 50
