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The Journal of Biochemistry and Cell Biology is an open access journal that showcases seminal research in Biochemistry and Cell Biology. This peer-reviewed journal covers a wide spectrum of experimental research and up-to-date analysis of biochemical traits of cellular and molecular biology in eukaryotes and prokaryotes.
Topics of interest include, but are not limited to:
• Protein structure/function analysis
• Biophysical techniques
• NMR spectroscopy and X-ray crystallography
• Enzyme catalytic mechanisms
• Cell signalling pathways
• Cytoskeletal proteins
• Gene expression regulation and metabolism
• Metabolic pathways
• Signaling pathways
• Organelle structure and function
• Cell death
The Editorial Board comprised of noted scholars in the fields of Biochemistry and Cell Biology provides unbiased but, rigorous review on the manuscript. In addition to Research Articles, the Journal also publishes high quality Commentaries, Reviews, and Perspectives aimed at synthesizing the latest developments in a coherent fashion.
Journal of Biochemistry and Cell Biology takes immense pride in providing the authors with an efficient publishing process. The Journal offers an encouraging platform for the authors to contribute their latest findings in this field.
Submit manuscript at https://www.editorialmanager.com/scholarlyjournals/ or send as an e-mail attachment to the Editorial Office at: [email protected] or [email protected]
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Biochemistry is the study of chemical processes within and relating to living organisms. By controlling information flow through biochemical signaling and the flow of chemical energy through metabolism, biochemical processes give rise to the complexity of life. Biochemistry is closely related to molecular biology, the study of the molecular mechanisms by which genetic information encoded in DNA is able to result in the processes of life. Much of biochemistry deals with the structures, functions and interactions of biological macro-molecules, such as proteins, nucleic acids, carbohydrates and lipids, which provide the structure of cells and perform many of the functions associated with life.
Biophysics is an interdisciplinary science that applies the approaches and methods of physics to study biological systems. Biophysics covers all scales of biological organization, from molecular to organismic and populations. Biophysical research shares significant overlap with biochemistry, physical chemistry, nanotechnology, bioengineering, computational biology, biomechanics and systems biology
The biophysical techniques provide information about the electronic structure, size, shape, dynamics, polarity, and modes of interaction of biological molecules. Some of the most exciting techniques provide images of cells, subcellular structures, and even individual molecules. It is now possible to directly observe the biological behaviour and physical properties of single protein or DNA molecules within a living cell and determine how the behaviour of the single molecule influences the biological function of the organism.
Cancer Biology is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Cancer cells behave as independent cells, growing without control to form tumors. Tumors grow in a series of steps. The first step is hyperplasia, meaning that there are too many cells resulting from uncontrolled cell division.
Cellular biochemistry is the study of all sorts of processes that occur within a biological cell and also interactions between different cells. Studies include bimolecular structures, biochemical mechanisms i.e., metabolic pathways, their control, physiological importance and clinical relevance. The regulatory studies cover gene expression, post-translational modifications of proteins, epigenetic controls etc.
Lipids are water insoluble biomolecules but soluble in non-polar solvents. Lipids have diverse structures including phospholipids, sphingolipids, vitamins, fatty acids, pigments, cholesterol and many more. Lipid biochemistry mainly deals with biological synthesis and signalling of lipids.
Cells are the basic building blocks of all living things. The human body is composed of trillions of cells. They provide structure for the body, take in nutrients from food, convert those nutrients into energy, and carry out specialized functions.
Cell biology explains the structure, organization of the organelles they contain, their physiological properties, metabolic processes, signalling pathways, life cycle, and interactions with their environment. This is done both on a microscopic and molecular level as it encompasses prokaryotic cells and eukaryotic cells
Cell death is the event of a biological cell ceasing to carry out its functions. This may be the result of the natural process of old cells dying and being replaced by new ones, or may result from such factors as disease, localized injury, or the death of the organism of which the cells are part. Kinds of cell death include the following:
1.Programmed cell death (or PCD) is cell death mediated by an intracellular program. PCD is carried out in a regulated process, which usually confers advantage during an organism's life-cycle. PCD serves fundamental functions during both plant and metazoa (multicellular animals) tissue development.
2. Apoptosis or Type I cell-death, and autophagy or Type II cell-death are both forms of programmed cell death, while necrosis is a non-physiological process that occurs as a result of infection or injury. Necrosis is cell death caused by external factors such as trauma or infection, and occurs in several different forms.
3. Programmed necrosis, called necroptosis, as an alternate form of programmed cell death. It is hypothesized that necroptosis can serve as a cell-death backup to apoptosis when the apoptosis signalling is blocked by endogenous or exogenous factors such as viruses or mutations.
4. Mitotic catastrophe is a mode of cell death that is due to premature or inappropriate entry of cells into mitosis. It is the most common mode of cell death in cancer cells exposed to ionizing radiation and many other anti-cancer treatments.
Cell morphology is essential in identifying the shape, structure, form, and size of cells. In bacteriology, for instance, cell morphology pertains to the shape of bacteria if cocci, bacilli, spiral, etc. and the size of bacteria. Thus, determining cell morphology is essential in bacterial taxonomy.
Membrane trafficking is the process by which proteins and other macromolecules are distributed throughout the cell, and released to or internalised from the extracellular space. Membrane trafficking uses membrane-bound vesicles as transport intermediaries
Cell signalling is part of any communication process that governs basic activities of cells and coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Errors in signalling interactions and cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. Systems biology research helps us to understand the underlying structure of cell signalling networks and how changes in these networks may affect the transmission and flow of information (signal transduction). Such networks are complex systems in their organization and may exhibit a number of emergent properties including bistability and ultra-sensitivity. Analysis of cell signalling networks requires a combination of experimental and theoretical approaches including the development and analysis of simulations and modelling.
Cytoskeletal proteins are proteins that make up the cytoskeleton, flagella or cilia of cells. Generally, cytoskeletal proteins are polymers, and include tubulin (the protein component of microtubules), actin (the component of microfilaments) and lamin (the component of intermediate filaments).
Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of regeneration, asexual reproduction, metamorphosis, and the growth and differentiation of stem cells in the adult organism.
Enzymology is the study of enzymes, their kinetics, structure, and function, as well as their relation to each other.
Enzyme catalysis is the increase in the rate of a chemical reaction by the active site of a protein. The protein catalyst (enzyme) may be part of a multi-subunit complex, and/or may transiently or permanently associate with a Cofactor. Catalysis of biochemical reactions in the cell is vital due to the very low reaction rates of the uncatalysed reactions at room temperature and pressure. A key driver of protein evolution is the optimization of such catalytic activities via protein dynamic.
Regulation of gene expression includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA), and is informally termed gene regulation
Genetics is the study of genes, genetic variation, and heredity in living organisms. It is generally considered a field of biology, but intersects frequently with many other life sciences and is strongly linked with the study of information systems. Genetic processes work in combination with an organism's environment and experiences to influence development and behaviour, often referred to as nature versus nurture.
Genomics is an interdisciplinary field of science focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes. The field also includes studies of intragenomic (within the genome) phenomena such as epistasis (effect of one gene on another), pleiotropy (one gene affecting more than one trait), heterosis (hybrid vigour), and other interactions between loci and alleles within the genome.
Regulation of gene expression includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA), and is informally termed gene regulation.
A metabolic pathway is a linked series of chemical reactions occurring within a cell. The reactants, products, and intermediates of an enzymatic reaction are known as metabolites, which are modified by a sequence of chemical reactions catalysed by enzymes. In most cases a metabolic pathway, the product of one enzyme acts as the substrate for the next. However, set products are considered waste and removed from the cell. These enzymes often require dietary minerals, vitamins, and other cofactors to function.
Molecular Metabolism is committed to serving as a platform reporting breakthroughs from all stages of the discovery and development of novel and improved personalized medicines for obesity, diabetes and associated diseases.
Neurobiology is the branch of biology that deals with nervous system functions and structures. More specifically, neurobiology focuses on the cells and tissues of the nervous system and ways in which they can form structures and circuits (pathways) for controlling the body. This system includes common structures, such as the brain and spinal cord, and nerves. Neurobiology can be classified as a sub-discipline within the broader field of physiology. It is relatively broad as a scientific field, and can be applied to multiple organism types, including humans, vertebrate animals (animals with backbones), and invertebrates (animals without backbones). The term 'neurobiology' is often used as a substitute for neuroscience, but the key distinction is that neurobiology is often limited to just the biological aspect of this system, and not the interdisciplinary aspects that we see in neuroscience.
NMR spectroscopy and X-ray crystallography are two premium methods for determining the atomic structures of macro-biomolecular complexes. The two techniques are highly complementary; they have generally been used separately to address the structure and functions of biomolecular complexes.
Organisms are composed of cells, and these cells have specific structures within in them that allow them to carry out their functions. These structures are called Organelles. Organelles perform different functions within a cell, and this is called the Division of Labour.
Protein analysis is the bioinformatic study of protein structure and function using database searches, sequence comparisons, structural and functional predictions.
Proteomics is the large-scale study of proteins. Proteins are vital parts of living organisms, with many functions. The proteome is the entire set of proteins that are produced or modified by an organism or system. This varies with time and distinct requirements, or stresses, that a cell or organism undergoes. It is an important component of functional genomics. Proteomics generally refers to the large-scale experimental analysis of proteins; it is often specifically used for protein purification and mass spectrometry.
Ribonucleic acid or RNA is one of the three major biological macromolecules that are essential for all known forms of life (along with DNA and proteins). A central tenet of molecular biology states that the flow of genetic information in a cell is from DNA through RNA to proteins: “DNA makes RNA makes protein”.
A group of molecules in a cell that work together to control one or more cell functions, such as cell division or cell death. After the first molecule in a pathway receives a signal, it activates another molecule.
Signal transduction is the transmission of molecular signals from a cell's exterior to its interior. Signals received by cells must be transmitted effectively into the cell to ensure an appropriate response. This step is initiated by cell-surface receptors.
Structural biology is a branch of molecular biology, biochemistry, and biophysics concerned with the molecular structure of biological macromolecules (especially proteins, made up of amino acids, and RNA or DNA, made up of nucleic acids), how they acquire the structures they have, and how alterations in their structures affect their function