Development and Evaluation of Mucoadhesive Patch Using a Natural Polysaccharide Isolated from Cordia dichotoma Fruit
Received Date: Oct 14, 2014 / Accepted Date: Nov 17, 2014 / Published Date: Nov 22, 2012
Mucoadhesive formulations have been developed for oral, buccal, nasal, ocular, rectal and vaginal routes for either systemic or local effects. This drug delivery system is suitable for drugs undergoing high first pass metabolism. It improves bioavailability, reduces dosing frequency and thereby minimizes the side effects and also makes the dosage forms more cost effective. In the present study, polysaccharide derived from the fruits of Cordia dichotoma (Family-Boraginaceae) was investigated as a mucoadhesive polymer in oral (Buccal or sublingual) patch formulation. Ramipril, an antihypertensive drug, was selected as a model drug. The patches of Ramipril were prepared separately using different concentrations (2.5%, 5%, 7.5% and 10%) of isolated Cordia dichotoma fruit polysaccharide (Natural) by solvent casting method. The prepared patches were evaluated for various parameters. The drug excipient interactions were characterized by FTIR studies. The formulation F4 showed good swelling index with excellent mucoadhesive strength and convenient residence time as well as slow and sustained drug release.
Keywords: Mucoadhesive Patch; Cordia dichotoma; Solvent Casting; Boraginaceae
Citation: Pawar AH, Surekha MJ, Pravin TJ, Rachel G (2014) Development and Evaluation of Mucoadhesive Patch Using a Natural Polysaccharide Isolated from Cordia dichotoma Fruit. J Mol Pharm Org Process Res 2: 120. Doi: 10.4172/2329-9053.1000120
Copyright: ©2014 Pawar AH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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