alexa Differences in Expression of Fatty Acid Synthase among Histological Subtypes of Intraductal Papillary Mucinous Neoplasm of the Pancreas – An Experience of Immune Histochemical Analysis
ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
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Research Article

Differences in Expression of Fatty Acid Synthase among Histological Subtypes of Intraductal Papillary Mucinous Neoplasm of the Pancreas – An Experience of Immune Histochemical Analysis

Hiroshi Maekawa1*, Hajime Orita1, Tomoaki Ito1, Mutsumi Sakurada1, Tomoyuki Kushida1, Koichi Sato1 and Ryo Wada2

1Department of Surgery, Juntendo University School of Medicine, Shizuoka Hospital, Shizuoka, Japan

2Department of Pathology, Juntendo University School of Medicine, Shizuoka hospital, Shizuoka, Japan

*Corresponding Author:
Hiroshi Maekawa
Department of Surgery
Juntendo University School of Medicine
Shizuoka Hospital, Shizuoka, Japan
Tel: +81 55.948.3111
Fax: +81 55.946.0514
E-mail: [email protected]

Received date: June 14, 2013; Accepted date: September 30, 2013; Published date: October 10, 2013

Citation: Maekawa H, Orita H, Ito T, Sakurada M, Kushida T, et al. (2013) Differences in Expression of Fatty Acid Synthase among Histological Subtypes of Intraductal Papillary Mucinous Neoplasm of the Pancreas – An Experience of Immune Histochemical Analysis. J Gastroint Dig Syst 3:144. doi:10.4172/2161-069X.1000144

Copyright: © 2013 Maekawa H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Fatty acid synthase plays an important role in tumorigenesis. We investigated the expression of fattyacid synthase in cases of intraductal papillary mucinous neoplasm of the pancreas, thought to be one of the precancerous lesions of pancreatic cancer, using immunohistochemistry. We also examined whether there are any differences between histological subtypes in intraductal papillary mucinous neoplasm of the pancreas. Methods: Eight cases of intraductal papillary mucinous neoplasm were examined using immunohistochemistry. Fatty acid synthase and Ki-67 expressions were investigated, and positive cellular rates were compared with histological subtypes of intra-ductal papillary mucinous neoplasm. Results: Pathologically, cases of the gastrictype were represented as low-grade dysplasia; however, cases of the intestinal or pancreatobiliary type were classified as intermediate- or high-grade dysplasia. Concerning fatty acid synthase expression, positive cellular rates of the gastric type were lower than those in cases of the intestinal or pancreatobiliary type. The positive cellular rates of Ki-67 expression were similar to those of fatty acid synthase expression. Conclusion: Although this study included only a small sample number, fatty acid synthase expression differed between the gastric and other subtypes in intraductal papillary mucinous neoplasm of the pancreas.

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