World Journal of Pharmacology and Toxicology
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  • Research Article   
  • World J Pharmacol Toxicol,

Effects of Lead and Sucroses Long-Term Consumption on Biochemical and Behavioral Parameters in Aging Rats

Perottoni J1, Fachinetto R2, Oliveira CS3, Wagner C4, Rocha JBT3,5 and Barbosa NV3,5*
1Department of Health Sciences, Federal University of Santa Maria, Palmeira das Missões Campus, RS, Brazil
2Department of Physiology And Pharmacology, Health Sciences Center, Federal University of Santa Maria, Santa Maria, RS, Brazil
3Postgraduate Program in Biological Sciences: Toxicological Biochemistry, Federal University of Santa Maria, Santa Maria, RS, Brazil
4Federal University of Pampa, Campus Caçapava do Sul, Caçapava do Sul, RS, Brazil
5Department of Biochemistry and Molecular Biology, Center for Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil
*Corresponding Author : Barbosa NV, Department of Biochemistry and Molecular Biology, Center for Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil, Tel: 55-55 3220 8140, Email: nvbarbosa@yahoo.com.br

Received Date: Apr 21, 2018 / Accepted Date: May 07, 2018 / Published Date: May 14, 2018

Abstract

Lead is a well know neurotoxic metal whose exposure has been associated with hyperglycemia and insulin resistance. Sucrose is a worldwide consumed foodstuff and experimental data have indicated that its intake can disrupt glucose metabolism in different animal models. The aim of this study was to investigate whether the simultaneous exposure to these agents could enhance the incidence of orofacial dyskinesia (OD) as well as alter behavioral and hematological parameters in aging rats. The experiments were conducted in female Wistar rats, which received lead acetate (Pb2+ 100 or 400 ppm) in drink water, 20% of sucrose or sucrose plus lead (100 or 400 ppm) for 12 months. The incidence of OD increased significantly as a function of age. The ingestion of lead and/or sucrose per se was not associated with an increase in OD occurrence. However, Pb2+ (400 ppm) when associated with sucrose decreased OD incidence. The locomotor activity of animals decreased in function of age, but was not changed by sucrose plus Pb2+ consumption. In addition to body weight gain, sucrose intake lowered the hematocrit and increased the blood levels of insulin and glucose of animals. Most of these effects were not induced and/or exarcebated by Pb2+. Our findings confirm that the aging culminates with OD onset and that the chronic consumption of Pb2+ or sucrose did not cause further increase in this condition. It is possible that some adaptative mechanism(s) have been developed to block the neurotoxicity of Pb2+ and/or sucrose after long-term exposure as verified in locomotor activity and OD. Interesting, here we described for the first time that prolonged ingestion of sucrose causes anemia in aging rats.

Keywords: Lead acetate; Sucrose; Orofacial dyskinesia; Anemia

Citation: Perottoni J, Fachinetto R, Oliveira CS, Wagner C, Rocha JBT, et al. (2018) Effects of Lead and Sucroses Long-Term Consumption on Biochemical and Behavioral Parameters in Aging Rats. World J Pharmacol Toxicol 1: 103.

Copyright: © 2018 Perottoni J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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