alexa Efficacy of Lubiprostone in Chronic Constipation: Clini
ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
Open Access

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Research Article

Efficacy of Lubiprostone in Chronic Constipation: Clinical and Work Productivity Outcomes

Tatsuya Abe1*, Yoshikazu Hachiro1, Yoshiaki Ebisawa1, Houhei Hishiyama1, Masanori Murakami2 and Masao Kunimoto1

1Department of Proctology, Kunimoto Hospital, Asahikawa, Japan

2Department of Gastroenterology, Kunimoto Hospital, Asahikawa, Japan

*Corresponding Author:
Tatsuya Abe
Kunimoto Hospital, 1-7-2-1 Akebono
Asahikawa 070-0061, Japan
Tel: +81-166-25-2241
Fax: +81-166-23-1726
E-mail: [email protected]

Received date: July 23, 2014; Accepted date: September 25, 2014; Published date: September 30, 2014

Citation: Abe T, Hachiro Y, Ebisawa Y, Hishiyama H, Murakami M, et al. (2014) Efficacy of Lubiprostone in Chronic Constipation: Clinical and Work Productivity Outcomes. J Gastroint Dig Syst 4:223. doi:10.4172/2161-069X.1000223

Copyright: © 2014 Abe T G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objective: Chronic constipation is a common health problem that significantly affects the quality of life of patients
and results in high economic burden. This clinical study was performed to assess the efficacy of lubiprostone in the
treatment of chronic constipation using a validated constipation scoring system and the work productivity and activity
impairment questionnaire.
Methods: We prospectively enrolled 35 patients who received lubiprostone. All the patients had chronic
constipation as defined by the Rome III criteria. The patients were treated orally with a 24-μg lubiprostone capsule
twice a day. Changes in the scores before and 2 weeks after the beginning of administration were recorded and
Results: Of the 35 patients, 28 completed the study and were included in the efficacy analysis. The total
constipation scoring system score was significantly improved from 11.3 ± 4.8 at baseline to 8.0 ± 4.0 after 2 weeks.
Although the work activity subscale did not show a significant improvement, such an improvement was statistically
significant in the case of non-work-related activities.
Conclusion: Our results demonstrate that lubiprostone is effective in improving many chronic constipationrelated
symptoms as well as the quality of life in patients with chronic constipation.


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