Abstract

Lipoprotein(a) is a unique plasma protein that has garnered increasing attention in recent years due to its significant association with cardiovascular risk. This comprehensive review aims to explore the genetic determinants of Lp(a) levels, its diverse roles in cardiovascular pathogenesis, and its impact on various cardiovascular conditions, with a particular focus on coronary artery disease (CAD) and degenerative aortic valve stenosis (DAS). Through an in-depth analysis of the literature, this review highlights the multifaceted nature of Lp(a) and its implications for risk assessment and preventive strategies in clinical practice.