Abstract

Biodegradable polymer implants have revolutionized the field of regenerative medicine by facilitating tissue regeneration and reducing the risks associated with permanent implants. Understanding the underlying cell signaling pathways that govern the biocompatibility of these materials is essential for optimizing their performance and enhancing patient outcomes. This article reviews the key signaling cascades—such as integrin-mediated signaling, the mitogen-activated protein kinase (MAPK) pathway, and the phosphoinositide 3-kinase (PI3K)-Akt pathway— implicated in the interactions between biodegradable polymers and cells. The modulation of these pathways can significantly influence cellular behaviors, such as adhesion, proliferation, and differentiation, ultimately impacting the biocompatibility of these implants. By elucidating these processes, we can design better biomaterials that promote tissue integration and healing.