Abstract

Epigenetic modifications, including DNA methylation, histone alterations (acetylation, methylation), and non-coding RNAs, are critical drivers of cardiac aging and disease progression. These mechanisms meticulously regulate gene expression, promote cellular senescence, and profoundly impair myocyte proliferation and regenerative capacity. Furthermore, they significantly contribute to cardiac dysfunction, adverse remodeling, and fibrosis in the aging heart. Understanding these intricate epigenomic changes provides critical insights into the pathogenesis of age-related cardiovascular decline. Targeting these specific epigenetic pathways offers promising therapeutic strategies for mitigating cardiac aging and improving heart health