alexa Evaluation of Antioxidant, Analgesic and Antidiarrheal Activities of Methanolic Extract of <em>Litsea monopetala</em> (roxb.) Leaves | OMICS International| Abstract
ISSN: 2167-065X

Clinical Pharmacology & Biopharmaceutics
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
  • Research Article   
  • Clin Pharmacol Biopharm,
  • DOI: 10.4172/2167-065X.1000185

Evaluation of Antioxidant, Analgesic and Antidiarrheal Activities of Methanolic Extract of Litsea monopetala (roxb.) Leaves

Md. Razowanul Ferdous1, Md Ashrafudoulla1, Md. Shohel Hossain1 and Sm Faysal Bellah1,2*
1Department of Pharmacy, School of Engineering, Science and Technology, Manarat International University, Dhaka-1216, Bangladesh
2Laboratory of Cellular Dynamics, School of Life Science, University of Science and Technology of China, Hefei, Anhui-230027, PR China
*Corresponding Author : Sm Faysal Bellah, Department of Pharmacy, School of Engineering, Science and Technology, Manarat International University, Dhaka-1216, Bangladesh, Tel: +8615656529539, Email: [email protected]

Received Date: Jun 01, 2018 / Accepted Date: Aug 20, 2018 / Published Date: Aug 30, 2018

Abstract

Antioxidant, analgesic and antidiarrheal activities of Litsea monopetala (LM) leaves extracts were investigated in order to assessment of pharmacological activities. In vitro antioxidant properties, in vivo analgesic and antidiarrheal activities were investigated in this study. Antioxidant plays a remarkable role to protect different kinds of diseases of human by inhibiting free radicals. 1, 1-diphenyl-2- picrylhydrazyl (DPPH) free radical scavenging was considered to evaluate the antioxidant property. Analgesic and antidiarrheal activities were investigated in acetic acid induced writhing and castor oil induced antidiarrheal method by white albino mice, respectively. Methanolic extract of LM leaves has shown antioxidant activity with an IC50 value of 223.22 μg/ml which was compared to the standard ascorbic acid. This extract of LM at a dose of 500 mg/kg showed statistically significantly (p<0.001) and produced 68.75% writhing inhibition of mice while standard diclofenac sodium drug has shown 76.25% inhibition. LM also produced a significant (P<0.01) reduction in the frequency of diarrhea produced by castor oil in mice compared with Loperamide (50 mg/kg) standard. This study clearly supports the medicinal value of LM`s leaves. However, further study is required to find out the active components which are responsible for these activities.

Keywords: Litsea monopetala (LM); Antioxidant; Analgesic; Antidiarrheal

Citation: Ferdous MR, Ashrafudolla M, Hossain MS, Bellah SF (2018) Evaluation of Antioxidant, Analgesic and Antidiarrheal Activities of Methanolic Extract of Litsea monopetala (roxb.) Leaves. Clin Pharmacol Biopharm 7: 185. Doi: 10.4172/2167-065X.1000185

Copyright: © 2018 Ferdous MR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Article Usage
  • Total views: 1825
  • [From(publication date): 0-0 - Nov 22, 2019]
  • Breakdown by view type
  • HTML page views: 1722
  • PDF downloads: 103
Top