The Neurologist: Clinical & Therapeutics Journal
Open Access

Evaluation of Hyperammonemia Risk Associated with Sodium Valproate Injection in Neurosurgery Patients During the Perioperative Period

Received Date: Mar 03, 2025 / Published Date: Mar 31, 2025

Copyright: © 0  . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

To read the full article Peer-reviewed Article PDF

Sodium valproate is commonly used in perioperative neurosurgery patients for seizure control and other therapeutic
purposes. However, its association with hyperammonemia, a potentially life-threatening condition, remains a significant
concern. This study evaluates the risk of hyperammonemia in neurosurgery patients receiving sodium valproate
injection during the perioperative period. A cohort of patients undergoing neurosurgical procedures was assessed for
ammonia levels pre- and post-operatively, alongside their valproate dosage and treatment duration. The results indicate
that elevated ammonia levels were significantly more common in patients receiving sodium valproate, particularly
at higher doses or in patients with pre-existing liver dysfunction. The study emphasizes the importance of closely
monitoring ammonia levels in these patients, especially in the perioperative phase when their risk may be heightened.
Recommendations for safe valproate usage and early identification of hyperammonemia are provided to mitigate
potential complications.

Keywords