ISSN: 2573-4555

Journal of Traditional Medicine & Clinical Naturopathy
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  • Research Article   
  • J Tradit Med Clin Natur ,
  • DOI: 10.4172/2573-4555.1000287

Exploration of the Hematological Profile of Male Sprague-Dawley Rats after Chronic Administration of an Ayurvedic Formulation Punarnavasava (PRV) Used in Ascites Treatment

Md Atikur Rahman1, Mohammad Tohidul Amin1*, Md. Abdul Aziz1, Kaniz Fatema2, Palash Karmakar1, Niloy Sen1 and M Shahabuddin Kabir Choudhuri3
1Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
2Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Noakhlai-3814, Bangladesh
3Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh
*Corresponding Author : Mohammad Tohidul Amin, Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh, Fax: 880-321-62788, Email: tamin1417925@gmail.com

Received Date: Jun 30, 2020 / Accepted Date: Jul 15, 2020 / Published Date: Jul 22, 2020

Abstract

Punarnavasava (PRV) is a classical Ayurvedic preparation and is very popular in rural areas due to its usage in the treatment of ascites. This study was conducted to explore the hemotoxicological effect of PRV after chronic administrations for 45 days to male Sprague-Dawley rats. After the observations, there were statistically significant changes in Basophil and Lymphocyte count (p=0.020 and p=0.032 respectively) but showed negligible changes for other hematological parameters like RBC, Hemoglobin, Hematocrit, Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), Erythrocyte sedimentation rate (ESR), etc. From these results, it can be concluded that PRV is less hemotoxic at higher doses and thus can be recommended to use safely in the treatment of ascites.

Keywords: Punarnavasava; Ascites; Hemotoxicity; Ayurvedic; RBC; WBC

Citation: Rahman MA, Amin MT, Aziz MA, Fatema K, Karmakar P, et al. (2020) Exploration of the Hematological Profile of Male Sprague-Dawley Rats after Chronic Administration of an Ayurvedic Formulation Punarnavasava (PRV) Used in Ascites Treatment. J Tradit Med Clin Natur 9: 287. Doi: 10.4172/2573-4555.1000287

Copyright: © 2020 Rahman MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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