Journal of Mucosal Immunology Research
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  • Research Article   
  • J Mucosal Immunol Res 2018: 104,

Expression of CXCR3 on Adaptive and Innate Immune Cells Contributes Oviduct Pathology throughout Chlamydia muridarum Infection

Janina Jiang1*, Heather Maxion1, Cheryl I. Champion1, Guangchao Liu1 and Kathleen A. Kelly1,2
1Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, , 10833 Le Conte Ave. CHS 1P-177, LA, CA 90095, USA
2California Nano Systems, University of California los Angeles, Los Angeles, California, USA
*Corresponding Author : Janina Jiang, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave. CHS 1P-177, LA, CA 90095, USA, Tel: 310-206-4910, Email: jjiang@mednet.ucla.edu

Received Date: Jul 10, 2017 / Accepted Date: Aug 28, 2017 / Published Date: Aug 31, 2017

Abstract

CXCR3 is a chemokine receptor expressed on a wide range of leukocytes, and it is involved in leukocyte migration throughout the blood and lymphatics. Specifically, CXCR3 is required for lymphocyte homing to the genital mucosa. When compared to wild type (WT) mice, CXCR3 deficiency (CXCR3-/-) mice infected with Chlamydia muridarum (C. muridarum) did not display impaired clearance and resolution of infection. However, they possessed significantly higher bacterial burden and lower levels of IFN-γ-producing TH1 cells. The knockouts also demonstrated a significant decrease in the level of activated conventional dendritic cells in the GT, ultimately leading to the decrease in activated TH1 cells. In addition, few activated plasmacytoid dendritic cells, which possess an inflammatory phenotype, were found in the lymph node of infected mice. This reduction in pDCs may be responsible for the decrease in neutrophils, which are acute inflammatory cells, in the CXCR3-/- mice. Due to the significantly reduced level of acute inflammation, these mice also possess a decrease in dilation and pathology in the oviduct. This demonstrates that the CXCR3- /- mice possess the ability to clear C. muridarum infections, but they do so without the increased inflammation and pathology in the GT.

Keywords: CXCR3; Immune cells; Adaptive immunity; Innate immunity; Oviduct pathology; Chlamydia muridarum infection

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