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Factors Associated with Confirmed Tuberculosis Treatment Outcome: A Hospital Study Cohort in Dakar, Senegal | OMICS International| Abstract
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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  • Research Article   
  • J Infect Dis Ther,
  • DOI: 10.4172/2332-0877.1000409

Factors Associated with Confirmed Tuberculosis Treatment Outcome: A Hospital Study Cohort in Dakar, Senegal

Louise Fortes Déguénonvo1*, Viviane Marie Pierre Cisse Diallo1, Khardiata Diallo Mbaye1, Agbogbenkou Tévi Déla Lawson2, Ndeye Aïssatou Lakhe1, Daye Ka1, Assane Diouf1, Ndeye Fatou Ngom Guèye3, Cheikh Tacko Diop3, Massaly Aminata1, Allasane Dieye1, Sylvie Diop-Nyafouna2, Cheikh Tidiane Ndour1 and Moussa Seydi1
1Department of Infectious and Tropical Diseases, Fann University Hospital, Dakar, Senegal
2UFR de Santé de Thiès, Thies, Senegal
3Alioune Diop University in Bambey, Bambey, Senegal
*Corresponding Author : Louise Fortes Déguénonvo, Department of Infectious and Tropical Diseases, Fann University Hospital, Dakar, Senegal, Tel: +00221775595333, Email: [email protected]

Received Date: Sep 17, 2019 / Accepted Date: Sep 26, 2019 / Published Date: Oct 03, 2019

Abstract

Context: In order to break the chain of tuberculosis transmission, all diagnosed cases must be followed until the treatment is complete. Several factors influence the treatment outcomes, particularly in hospitals where care is provided for patients with the most severe cases.

Methodology: The purpose of this retrospective cohort study was to analyze the evolution of the treatment outcomes from 2011 to 2015 and identify factors associated with unsuccessful TB treatment. Tuberculosis cases confirmed by bacteriology and/or by Xpert-MTB/Rif test, being treated in the Department of Infectious and Tropical Diseases at Fann University Hospital in Dakar, were included. The trend Ch2 test was used to measure the evolution of treatment outcomes from 2011 to 2015 and logistic regression for the identification of the factors associated with unsuccessful TB treatment.

Results: We collected 413 confirmed tuberculosis cases. The average age of patients was 38 ± 12 years and the sex ratio: 1.3. Most patients of the 46.4% cases were admitted to hospital. The average weight during the beginning of the treatment was 51 ± 10.8 kg. The isolated pulmonary TB represented 86.2%, followed by the multifocal TB 11.8%. Patients receiving retreatment were 8.2%. The HIV seroprevalence was 60.67%. Bacilloscopy confirmed tuberculosis in 75% of the cases and the Xpert-MTB/Rif test in 25%. From 2011 to 2015, the percentage of patients with successful TB treatment has increased from 47.4% to 69.3% (p=0.006). Lost to follow up patients have decreased from 18.4% to 7.4% (p=0.04). Unsuccessful TB treatment was associated to hospitalization at TB diagnosis (AOR=7.15; 95% CI: 4.23 – 12.10), low weight when starting the treatment (AOR=0.33; 95%CI: 0.14 – 0.77), and co-infection with HIV (AOR=2.07; 95% CI: 1.17 – 3.71).

Conclusion: Overall, progress has been made in monitoring patients who have been treated for tuberculosis. However, the favorable outcome percentage could be increased by improving the nutritional condition of patients and intensifying early screening and fighting against HIV infection.

Keywords: Tuberculosis; Confirmed; Treatment; Outcome

Citation: Déguénonvo LF, Cisse Diallo VMP, Mbaye KD, Déla Lawson AT, Lakhe NA, et al. (2019) Factors Associated with Confirmed Tuberculosis Treatment Outcome: A Hospital Study Cohort in Dakar, Senegal. J Infect Dis Ther 7: 409. Doi: 10.4172/2332-0877.1000409

Copyright: © 2019 Déguénonvo LF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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