Abstract

Diclofenac sodium-loaded solid lipid nanoparticles with guggul lipid as the main lipid component were created and tested for physical characteristics, permeation profile, and anti-inflammatory action. The SLNs were formed into gel after being assessed for physical parameters, in vitro drug release, and accelerated stability experiments. For ex vivo and in vivo drug penetration and anti-inflammatory effectiveness, the gels were compared to a commercial emulgel and a plain carbopol gel containing drug. The SLNs were stable and had ideal physical properties. The maximum in vitro drug release was achieved by GMS nanoparticle 1 and stearic acid nanoparticle 1. In receptor fluid, guggul lipid nanoparticle gel 3 had 104.68 times more drug than CEG. The enhancement ratio of GLNG-3 in comparison to CG was 39.43. At 4 hours, GLNG-3 was over 8.12 times greater than CEG. The AUC of GLNG-3 was 15.28 times greater than that of CEG.