Abstract

The gut microbiome is a key regulator of the gut-brain-muscle axis, profoundly influencing muscle function, metabolic health, neuroplasticity, and immune responses. Exercise and nutrition significantly modulate gut microbiota composition and function, impacting brain health, cognition, mood, and muscle integrity. Microbial metabolites like Short-Chain Fatty Acids mediate these systemic interactions. Targeting the gut microbiome through physical activity and dietary interventions offers promising therapeutic avenues for preventing muscle wasting, improving metabolic conditions, enhancing mental well-being, and bolstering immunity, with broad implications for holistic health and disease management.