Abstract

Helicobacter pylori (H.pylori) infection is known to cause varied clinical presentations and histological changes in the gastrointestinal tract. It may be one of the several mimickers of celiac disease. We present a case of a 48 year old female who presented with intermittent episodes of diarrhea, loss of appetite and weight loss. On evaluation she had Iron deficiency, megaloblastic anemia and hypoalbuminemia causing pedal edema. Histopathological examination of gastric and duodenal mucosa revealed H.pylori associated gastritis sprue like morphological changes in the duodenal mucosa. She was put on anti H.pylori regimen leading to rapid clinical improvement within two months of initiating treatment. Hence, the possibility of H.pylori induced duodenitis should also be considered in the differential diagnosis of chronic diarrhoeal diseases.

Keywords: Helicobacter pylori; Intraepithelial lymphocytosis; Duodenum