How CX3CR1+ Macrophages Regulate Gut Homeostasis
Giulia Marelli* and Paola Allavena
Department of Immunology and Inflammation, IRCCS-Humanitas Clinical and Research Center, Via manzoni, Rozzano, Italy
- *Corresponding Author:
- Giulia Marelli
Department Immunology and Inflammation
IRCCS-Humanitas Clinical and Research Center
Via manzoni, Rozzano, Italy
E-mail: [email protected]
Received date: April 06, 2017; Accepted date: June 20, 2017; Published date: June 25, 2017
Citation: Marelli G, Allavena P (2017) How CX3CR1+ Macrophages Regulate Gut Homeostasis. J Mucosal Immunol Res 1:102.
Copyright: © 2017 Marelli G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Colonic mucosa is a very peculiar immunological site daily exposed to a huge amount of harmless antigens. It is important for the immune system to be able to recognize this innocuous antigens from pathogens. Among all the immune cells, CX3CR1+ macrophages exploit this critical role. In this commentary on our recent publication on Immunobiology we want to highlight the crucial and unique role of these macrophages in order to maintain homeostasis and avoid the rise of aberrant inflammation and tissue damage.