Journal of Obesity and Metabolism
Open Access

Identification Inflammatory Biomarkers Associated with Metabolically Unhealthy Obesity in Adolescents: A Systematic Literature Review

Received Date: Jun 16, 2023 / Published Date: Jan 30, 2025

Citation: Lariwu CK, Susanti R, Cahyati WH, Rahayu RRSR (2025) Identification Inflammatory Biomarkers Associated with Metabolically Unhealthy Obesity in Adolescents: A Systematic Literature Review. J Obes Metab 8: 256.

Copyright: © 2025 Lariwu, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

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Prevalence obesity in children and adolescents keep going increase in a manner significant a number of this decades. Lots of research state that there is connection obesity with incidents disease like hypertension, abnormal blood sugar levels, dyslipidaemia, cancer even death. Children and youth with Metabolically Unhealthy Obesity (MUO) will experience 2 or more symptoms consist of blood pressure 130/85 mm Hg or more, rate triglycerides above 150 mg/dL, HDL levels 126 mg/dL. In other words that children and youth with the MOU has very high risk for experience disease metabolic. With identify biomarker inflammation, got estimate abnormality related metabolites with obesity in adolescents. The aim of this study is to identify and analyze associated inflammatory biomarkers with metabolically unhealthy obesity in adolescent. This study using method of literature systematic review with PRISMA guidelines for give explanation about associated inflammatory biomarkers with metabolically unhealthy obesity in adolescents. Search relevant article based on four step selection that is identification, screening, eligibility and data extraction. Using 10 relevant articles from 358 articles based on the PubMed data base. As a result, Body Mass Index (BMI) often used for diagnose circumstances obesity but BMI is not can explain circumstances abnormality metabolism of the obesity person. Inflammatory Biomarkers as a cellular mediator characteristic inflammation have a response system immunity body experience when BMI, circumference waist, circumference belly and circumference arm somebody exceed normal size. CRP or hs-CRP, TNF-α, IL-6, IL-8 and adiponectin is marker inflammation secreted by the body during adolescence experience obesity with MUO category. This study conclusion is teenager with MUO have a risk experience infection and inflammation, it has proven exists enhancement hs -CRP, TNF-α, IL-6, IL-8 and adiponectin than teenager with MHO.

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