Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar


Importance of Fluorine and Fluorocarbons in Medicinal Chemistry and Oncology | OMICS International| Abstract
ISSN: 2329-9053

Journal of Molecular Pharmaceutics & Organic Process Research
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Review Article   
  • J Mol Pharm Org Process Res 2013, Vol 1(2): 104
  • DOI: 10.4172/2329-9053.1000104

Importance of Fluorine and Fluorocarbons in Medicinal Chemistry and Oncology

Farid Menaa1*, Bouzid Menaa2 and Olga N Sharts1,2
1Fluorotronics, Inc., Department of Oncology, Stem Cells and Nanomedicine, , 2453 Cades Way, Bldg C, San Diego, CA 92081, USA
2Fluorotronics, Inc., Department of Chemistry and Nanobiotechnology, , 2453 Cades Way, Bldg C, San Diego, CA 92081, USA
*Corresponding Author : Farid Menaa, Department of Oncology, Stem Cells and Nanomedicine, 2453 Cades Way, Bldg C, San Diego, CA 92081, USA, Email:

Received Date: Mar 21, 2013 / Accepted Date: Apr 24, 2013 / Published Date: Apr 26, 2013


Carbon-Fluorine (C-F) can serve as a molecular tag for many applications in medicinal chemistry and oncology such as identification (i.e. screening), imaging (i.e. tracing) and analytical characterization. Thereby, fluorination, a chemical process to add a fluorine atom into a single molecule or a complex matrix materials (e.g. compounds) is largely used in the pharmaceutical field to confer some interesting properties to cancer drug compounds (e.g. enhancement of bioavailability). It is further more recently used for labelling some biological molecules of interest (i.e. peptides, nucleic acids) or nanomaterials (i.e. nanoparticles) which are of high importance for cancer chemoand biotherapy (e.g. immunotherapy) as well as for tumor (aka tumour)/cancer imaging (i.e. staging/prognosis, biodistribution, cancer diagnosis and therapy). Indeed, In addition to be easy-to-handle, efficient, soluble, smaller and cheaper, C-F bond is more stable than fluorescent dye, less toxic than fluorine radioisotopes, and less harmful than radio-waves. We have developed a patented technology called carbon-fluorine spectroscopy (CFS aka Spectro-Fluor®) along with methods and applications to not only specifically and sensitively detect C-F bonds in raw pure compound, complex materials but also to screen (e.g. drug discovery and drug security) as well as to trace F-molecules in vivo for improved medical care, particularly but not limited to the oncology sector (e.g. tumor/cancer imaging, development of new F- reagents, F-biomolecules, and anti-cancer agents). In this paper, we reviewed and discussed the major physical-chemical properties of C-F bond, the main applications of fluorocarbons as well as the state-of-art imaging technologies that use fluorine for clinical and research and development (R&D) oncology purposes (e.g. drug design, drug discovery, drug delivery and molecular imaging). An emphasis is put on the use of safer, unlabeled fluorinated molecules thanks to the emerging and promising CFS derived platform green technology that allows to reliably detecting unlabeled C-F molecules. Overall, we conclude that fluorine is a magical atom for molecular diagnosis and therapy that does not always need to be labelled.

Keywords: Fluorination; Carbone-Fluorine; Oncology; Nanomedicine; Pharmacy; Medicinal chemistry; Green chemistry; Green technology; Technological innovation; Carbon-fluorine spectroscopy; Nuclear magnetic resonance; Magnetic resonance imaging; Positron emission tomography

Citation: Menaa F, Menaa B, Sharts ON (2013) Importance of Fluorine and Fluorocarbons in Medicinal Chemistry and Oncology. J Mol Pharm Org Process Res 1: 104. Doi: 10.4172/2329-9053.1000104

Copyright: ©2013 Menaa F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.